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PPT mRNA was induced in medium\u2010sized (1,000\u20132,000 \u03bcm<jats:sup>2<\/jats:sup>) and large\u2010sized (&gt;2,000 \u03bcm<jats:sup>2<\/jats:sup>) cells in the DRG after axotomy. There was a 165% increase in the number of labeled cells after sciatic transection and a 260% increase after spinal nerve transection which results in axotomy of all the cells in the ganglion. The further increase after spinal nerve transection suggests that the induction occurred in axotomized neurons. PPT mRNA label was also present in a reduced number of small (&lt;1,000 \u03bcm<jats:sup>2<\/jats:sup>) cells after axotomy. SP immunoreactivity was also induced in medium\u2010and large\u2010sized cells and reduced in small\u2010sized cells. Our findings suggest that the expression of the PPT gene and SP is differentially regulated in different subpopulations of DRG neurons after axotomy and is consistent with the hypothesis that tachykinins may be important in both sensory transmission and regeneration. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490370506","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:57:52Z","timestamp":1104544672000},"page":"596-603","source":"Crossref","is-referenced-by-count":102,"title":["Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons"],"prefix":"10.1002","volume":"37","author":[{"given":"K.","family":"Noguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dubner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Senba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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