{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T02:51:46Z","timestamp":1720752706101},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,18]],"date-time":"2004-10-18T00:00:00Z","timestamp":1098057600000},"content-version":"vor","delay-in-days":3731,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monoamine\u2010activated \u03b1<jats:sub>2<\/jats:sub>\u2010macroglobulin (\u03b1<jats:sub>2<\/jats:sub>M) has been shown to inhibit choline acetyltransferase in basal forebrain neurons as well as neurotrophin\u2010dependent neuronal functions. The objective of this study was to determine whether monoamine\u2010activated \u03b1<jats:sub>2<\/jats:sub>M can affect the caudate putamen (CP) dopaminergic system in vivo. Male rats received intracranial infusions of methylamine\u2010activated \u03b1<jats:sub>2<\/jats:sub>M (0.6 nmole) and contralateral infusions of its vehicle, phosphate\u2010buffered saline (PBS). Five days following infusion, the animals were killed, the CP dissected into three rostral\u2010caudal segments, and assayed for dopamine (DA) using a high\u2010performance liquid chromatography system. Within the two rostral CP segments (the approximate site of cannula placement), statistically significant (26%) reductions of DA concentrations were obtained on the \u03b1<jats:sub>2<\/jats:sub>M\u2010infused side of the CP with 90\u2013100% of the animals showing decreases. At a more distal (caudal) site of the CP, DA concentrations showed only an insignificant (12%) reduction. No differences in DA concentrations between sides infused with bovine serum albumin versus PBS or from olfactory tubercle samples were obtained in these animals. These results demonstrate that monoamine\u2010activated \u03b1<jats:sub>2<\/jats:sub>M is capable of producing significant degeneration of the nigrostriatal dopaminergic system in vivo and suggest that this factor may play a role in age\u2010related neurodegenerative disorders such as Parkinson's disease. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490380506","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:00:55Z","timestamp":1104544855000},"page":"531-537","source":"Crossref","is-referenced-by-count":7,"title":["Intracranial infusion of monoamine\u2010activated \u03b1<sub>2<\/sub>\u2010Macroglobulin decreases dopamine concentrations within the rat caudate putamen"],"prefix":"10.1002","volume":"38","author":[{"given":"Y.\u2010Q.","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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