{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:56:07Z","timestamp":1758819367736},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":3663,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to examine whether axotomy\u2010induced motoneuron death in adult mammals differ: (1) with the distance between the site of injury and the nerve cell body, and (2) if contact between the transected nerve stumps is established after the injury, compared with cases where contact is prevented.<\/jats:p><jats:p>The hypoglossal nerve of adult rats was transected either proximally in the neck (proximal injury) or close to the tongue (distal injury). The nerve stumps were then either deflected from each other in order to prevent axon regeneration into the distal nerve stump, or sutured. Three months later, the extent of nerve cell loss was examined bilaterally in cresyl violet\u2010stained sections of the hypoglossal nucleus. In addition, we examined hypoglossal neuron survival twelve months after a proximal nerve transection with prevented regeneration.<\/jats:p><jats:p>Our results show that there was no significant difference in neuronal survival after a proximal nerve transection compared with a distal one, neither if contact between the nerve stumps was established nor if it was prevented. However, contact between the transected nerve stumps increased the likelihood of neuronal survival significantly after both proximally and distally located injury compared to nerve injury with prevented regeneration. There was no significant decrease in nerve cell survival after twelve months with prevented reinnervation compared with survival after three months.<\/jats:p><jats:p>These observations indicate that the extent of axotomy\u2010induced motoneuron death in adult mammals does not correlate with the proximo\u2010distal level of peripheral injury. Furthermore, early contact with the distal stump and\/or target musculature is a significant factor for the survival of axotomized motoneurns. However, more than 50% of the original nerve cell population survives a considerable time even after permanent disconnection from the target. Copyright \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490390206","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:02:01Z","timestamp":1104544921000},"page":"159-165","source":"Crossref","is-referenced-by-count":19,"title":["Motoneuron survival is not affected by the proximo\u2010distal level of axotomy but by the possibility of regenerating axons to gain access to the distal nerve stump"],"prefix":"10.1002","volume":"39","author":[{"given":"E.","family":"T\u00f5rnqvist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Aldskogius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_1_3_1","first-page":"191","volume-title":"Advances in Structural Biology 2","author":"Aldskogius H","year":"1993"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901930111"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040407"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90180-7"},{"key":"e_1_2_1_7_1","first-page":"29","article-title":"Molecular control of neuronal survival","volume":"5","author":"Barde YA","year":"1993","journal-title":"Restor. 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