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Treatment with 0.1\u20101.0\u03bcM forskolin, an activator of the cAMP\u2010generating enzyme adenylyl cyclase, increased the cAMP content up to 13\u2010fold, but was yet without effect on axonal outgrowth during an 8\u2010day culturing period. HA\u20101004, an inhibitor of cAMP\u2010dependent protein kinase, also lacked effect on the regeneraton. In contrast, the proliferation of Schwann cells, measured as [3H]thymidine incorporation, was inhibited to about 70% of control by forskolin, whereas HA\u20101004 stimulated proliferation to approximately 130% of control. The results suggest that cAMP is involved in the injury\u2010induced proliferation of Schwann cells of an adult peripheral nerve but that it lacks a central role in the regeneration of sensory axons of such nerves. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490420107","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:13:54Z","timestamp":1104545634000},"page":"54-62","source":"Crossref","is-referenced-by-count":6,"title":["Increased cyclic AMP in in vitro regenerating frog sciatic nerves inhibits Schwann cell proliferation bur has no effect on axonal outgrowth"],"prefix":"10.1002","volume":"42","author":[{"given":"P. A. 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