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Injury of the neurites emerging from the DRGs led to enhanced levels of PN\u20101 in Schwann cells located distal to the lesion site where degeneration of neuronal processes took place. In cultured sciatic nerve segments, PN\u20101 synthesis increased with a time\u2010course comparable to that in ganglion explants following lesion. In the third model, PN\u20101 levels gradually rose in isolated Schwann cells during the first 3\u20108 days in culture. Dissociation of Schwann cells from the sciatic nerve therefore causes an effect similar to nerve damage. Impairment of Schwann cell\u2010neuron interactions was followed by a reduction in the expression levels of the angiotensin II (Ang II) receptor subtype AT<jats:sub>1<\/jats:sub> in all three systems studied. Since the neuropeptide Ang II is able to repress PN\u20101 synthesis in cultured Schwann cells, loss of neuronal contact might decrease their responsiveness to Ang II, thus resulting in PN\u20101 upregulation by default. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490420414","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:14:15Z","timestamp":1104545655000},"page":"562-570","source":"Crossref","is-referenced-by-count":12,"title":["Regulation of protease nexin\u20101 and angiotensin II receptor subtype 1 expression: Inverse relationship in experimental models of nerve 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