{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:04:43Z","timestamp":1781827483323,"version":"3.54.5"},"reference-count":83,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WU392\/9\u20101"],"award-info":[{"award-number":["WU392\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Anxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), and psychosocial stress was induced with the imaging stress paradigm Scan\n                    <jats:italic>STRESS<\/jats:italic>\n                    . Anxiety, but not depression scores, were significantly related to neural stress responses in a striato\u2010limbic cluster. Moreover, relative to women, men showed stronger associations between anxiety scores and activation in striatal and temporal clusters. A bifactor model of the HADS suggested a general factor characterized by tension, nervousness, and cheerlessness, which was associated with activation changes in a similar but more circumscribed cluster than anxiety. In the LawSTRESS project, the HADS was assessed at five sampling points (1\u2009year, 3\u2009months, 1\u2009week prior exam, 1\u2009week, and 1\u2009month thereafter), and thus an exploratory trajectory analysis could be performed. It confirmed the relationship between anxiety scores and striatal stress responses at baseline but revealed no predictive value of the neural measure across the sampling points. Our results suggest that\u2014in healthy young participants\u2014neural acute psychosocial stress responses in striato\u2010limbic structures are associated with anxiety, supporting the assumption that these regions are related to individual differences in vulnerability to stress\u2010related disorders. A correlation with depression scores could not be found, and possible explanations are discussed.\n                  <\/jats:p>","DOI":"10.1002\/jnr.70019","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:02:02Z","timestamp":1737021722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between the Neural Stress Response and Symptoms of Anxiety and Depression"],"prefix":"10.1002","volume":"103","author":[{"given":"Marina","family":"Giglberger","sequence":"first","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina\u2010Isabelle","family":"Henze","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"},{"name":"Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t Zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"B\u00e4rtl","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Konzok","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"},{"name":"Department of Epidemiology and Preventive Medicine University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte M.","family":"Kudielka","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Kreuzpointner","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-8949","authenticated-orcid":false,"given":"Stefan","family":"W\u00fcst","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.09.019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.05.004"},{"key":"e_1_2_11_4_1","volume-title":"Beck Depression Inventory","author":"Beck A. 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