{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:15:17Z","timestamp":1773800117000,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011577","name":"Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["INM\u2010324"],"award-info":[{"award-number":["INM\u2010324"]}],"id":[{"id":"10.13039\/501100011577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011577","name":"Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["EST\/3009\/JRF\/2020"],"award-info":[{"award-number":["EST\/3009\/JRF\/2020"]}],"id":[{"id":"10.13039\/501100011577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Traumatic brain injury (TBI) is an insult to the brain that impacts neuronal and non\u2010neuronal cells\/tissues. The study aimed to understand TBI\u2010induced early changes in the brain and systemic physiology. The male rats were subjected to mild and moderate TBI, where serum and urine metabolic fingerprints of mild TBI rats showed a hypermetabolic response with increased energy metabolites, amino acids, and gut metabolites in serum and increased TCA cycle intermediates in urine. In contrast, the moderate TBI rats showed decreased lactate, pyruvate, amino acids (glycine and leucine) and gut metabolites [trimethylamine N OXIDE (TMAO), choline and acetate] in serum. The urine showed increased pyruvate, creatinine, and allantoin levels. To understand the brain's role in altered metabolic physiology, hypothalamus structure was assessed using diffusion tensor imaging (DTI) and stress levels were observed using serum corticosterone. The injured rats exhibited changes in DTI metrics in the hypothalamus, suggesting a potential disruption in the regulation of the hypothalamus\u2010pituitary\u2013adrenal axis (HPA) axis. These alterations were accompanied by increased TNF\u2010\u03b1 levels after moderate TBI. The injury induced allostatic overload, accompanied by impaired hypothalamic structure, and metabolic physiology also showed gut microbiome dysbiosis. The gut microbiome showed an increased Firmicutes: Bacteroidetes ratio after injury, with variable gut composition after both injuries. Therefore, the present study provides insight into an interplay between the HPA axis, metabolism, and gut microbiome following TBI. Importantly, this crosstalk between the regulatory systems was different after mild and moderate injury, highlighting the need to assess injury phenotype based on the severity.<\/jats:p>","DOI":"10.1002\/jnr.70032","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T11:34:20Z","timestamp":1743593660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Interplay Between Hypothalamic Microstructure, Systemic Metabolism and Gut Microbiome Composition in Male Rats at Hyperacute Timepoint Post\n                    <scp>TBI<\/scp>"],"prefix":"10.1002","volume":"103","author":[{"given":"Palkin","family":"Arora","sequence":"first","affiliation":[{"name":"Radiological, Nuclear and Imaging Sciences (RNAIS) Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO  Delhi India"},{"name":"Department of Biochemistry Panjab University  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Radiological, Nuclear and Imaging Sciences (RNAIS) Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO  Delhi India"},{"name":"Department of Biotechnology Delhi Technological University (DTU)  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Singh","sequence":"additional","affiliation":[{"name":"Radiological, Nuclear and Imaging Sciences (RNAIS) Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Memita","family":"Devi","sequence":"additional","affiliation":[{"name":"Radiological, Nuclear and Imaging Sciences (RNAIS) Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Rana","sequence":"additional","affiliation":[{"name":"Radiological, Nuclear and Imaging Sciences (RNAIS) Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-5811","authenticated-orcid":false,"given":"Rajat","family":"Sandhir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Panjab University  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-2622","authenticated-orcid":false,"given":"Richa","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Radiological, Nuclear and Imaging Sciences (RNAIS) Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15171"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201002005\u2010x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188318"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306\u2010022\u201001886\u20108"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5326"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00408"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2021.10.003"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010022\u201001092\u20100"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.03.014"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010011\u20100119\u20108"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5816837"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181568d9f"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.09.011"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.04.010"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010021\u201003544\u20102"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130054"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143777"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.831825"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091259"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010820683\u20106.00014\u20102"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051051"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082873"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00190"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100849"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281951"},{"key":"e_1_2_13_28_1","first-page":"55","volume-title":"Handbook of Clinical Neurology, Sex Differences in Neurology and Psychiatry","author":"Leistner C.","year":"2020"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7030059"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551\u20106776\u201019.4.277"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011\u20102176"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4634172"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1550\u20102783\u20101\u20102\u20107"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6885"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166491"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0009\u20108981(01)00608\u20108"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.580171"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075198\u2010200204000\u201000002"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00528"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7506"},{"key":"e_1_2_13_41_1","volume-title":"The Rat Brain in Stereotaxic Coordinates: Hard Cover Edition","author":"Paxinos G.","year":"2006"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012\u20101484"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.105046"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2018.03454"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111715"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20100897\u20104_8"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128214"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00345"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091409"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030227\u20105"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23073"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061843"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1849998"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8110326"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103688"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6780"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800536"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010018\u20109371\u20104"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2016-025"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp356"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179519"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173467"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.70032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:07:56Z","timestamp":1754906876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.70032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jnr.70032"],"URL":"https:\/\/doi.org\/10.1002\/jnr.70032","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.70032\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70032\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70032"}}