{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:12:30Z","timestamp":1791267150280,"version":"4.1.0"},"reference-count":120,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social deficits, restricted interest, and repetitive behaviors. The prevalence is higher in males (4:1). FDA\u2010approved drugs, Aripiprazole, and risperidone, only target comorbid conditions and have significant side effects. Dysregulation in cAMP\u2010responsive element\u2010binding protein (CREB) signaling is reported in autistic individuals. Forskolin is traditionally used in Ayurvedic medicine with lesser side effects. It is a potent adenylyl cyclase (AC) activator, increases intracellular cyclic adenosine monophosphate (cAMP) levels, thereby activating the protein kinase A (PKA)\/CREB pathway with clinically proven benefits as an anticancer, anti\u2010asthmatic, and in metabolic disorder, and crosses the blood\u2013brain\u2010barrier (BBB) junction. The present study aimed to investigate the impact of Forskolin and sought to explore the role of estrogen beta (ER\u03b2\/ESR2) receptors in a valproic acid (VPA) model of ASD. Pregnant Wistar rats received VPA or an equal volume of saline on gestational day (GD) 12.5. From postnatal day (PND) 23, male and female rats were divided separately into control, VPA, risperidone, and Forskolin (10\u201330\u2009mg\/kg) groups. Systemic administration of Forskolin ameliorated anxiety, social deficit, repetitive behavior, spatial recognition memory, motor coordination, gastrointestinal (GIT) motility, brain edema, and BBB permeability in a dose\u2010dependent manner. Moreover, chronic Forskolin treatment significantly alleviated VPA\u2010induced neuronal damage in the prefrontal cortex (PFC), hippocampus (HC), and cerebellum, and increased the intracellular CREB ser133 protein phosphorylation. Forskolin upregulated the mRNA expression of CREB signaling, which was altered by prenatal VPA administration. Our findings indicate that Forskolin provides neuroprotection through CREB signaling, suggesting its therapeutic potential for ASD.<\/jats:p>","DOI":"10.1002\/jnr.70049","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:19:22Z","timestamp":1748920762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adenylyl Cyclase Activator: Forskolin Mediates\n                    <scp>CREB<\/scp>\n                    ser133 Phosphorylation in the Hippocampus, Alleviates Autism\u2010Like Deficits in a Valproic Acid Model of Wistar Rats"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-3209","authenticated-orcid":false,"given":"Ashish","family":"Jain","sequence":"first","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Dhir","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praisy K","family":"Prabha","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Raja","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Raj","family":"Sharma","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"},{"name":"Department of Neurology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamanna","family":"Kaundal","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Charan","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibyajyoti","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biman","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepy","family":"Zohmangaihi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj K.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Neurology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-641X","authenticated-orcid":false,"given":"Bikash","family":"Medhi","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-8482","authenticated-orcid":false,"given":"Ajay","family":"Prakash","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology Laboratory (EPL), Neurobehavioral Research Laboratory (NBRL), Department of Pharmacology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90659-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240898"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8050318"},{"key":"e_1_2_12_5_1","article-title":"Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive\u2010Like Behaviors in Mice","volume":"82","author":"Angoa\u2010P\u00e9rez M.","year":"2013","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2018.16.2.129"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6706a1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172091899"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158417"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-418700-9.00001-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01742-2"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2022.772792"},{"key":"e_1_2_12_14_1","first-page":"60","article-title":"Forskolin Activation of Human Myocardial Adenylate\u2010Cyclase","volume":"68","author":"Bristow M.","year":"1983","journal-title":"Circulation"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722272.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02611-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2336"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000718628.09065.1b"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb08660.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610030205"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10137"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2005.02.003"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-02161-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(93)90307-P"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031385\u20107"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110185"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.716673"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2021-111804"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-016-0110-z"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025054610557"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819e7203"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.01.007"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174469"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP7352"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.162"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22831"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400210"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.004"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25217"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02531-0"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-2-2-54"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00182"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800229"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.03.023"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.2022.4410.1"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.IJP_518_19"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023751"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.010"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050759"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmu.2016.02.001"},{"issue":"4","key":"e_1_2_12_51_1","first-page":"100","article-title":"Autistic Disturbances of Affective Contact","volume":"35","author":"Kanner L.","year":"1968","journal-title":"Acta Paedopsychiatrica"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11182771"},{"issue":"4","key":"e_1_2_12_53_1","first-page":"278","article-title":"Coleus Forskohlii: A Comprehensive Review on Morphology, Phytochemistry and Pharmacological Aspects","volume":"4","author":"Kavitha C.","year":"2010","journal-title":"Journal of Medicinal Plant Research"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2013.29.3.173"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1266"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.10.052"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.03.013"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2015.10.007"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2022.20.4.725"},{"issue":"7","key":"e_1_2_12_60_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0122-1","article-title":"It Is Time to Integrate Sex as a Variable in Preclinical and Clinical Studies","volume":"50","author":"Lee H.","year":"2018","journal-title":"Experimental & Molecular Medicine"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112000"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01499-6"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.813304"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115483"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00828-0"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab115"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2357"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20392"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2023.12.008"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115734072278540231229120913"},{"issue":"2","key":"e_1_2_12_71_1","first-page":"200","article-title":"A Novel Non\u2013Receptor and Non\u2010Gabaergic Antianxiety\u2010Like Activity of Forskolin: Synergy With Diazepam","volume":"7","author":"Malik R.","year":"2015","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_12_72_1","first-page":"243","volume-title":"Handbook of Methods for Oxygen Radical Research","author":"Marklund S.","year":"1985"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.04.001"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085068"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.270316"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.02.003"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-10-04146.2003"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.008"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-019-04234-3"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw043"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.01292"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.3897\/phytokeys.129.34988"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4542-03.2004"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20943823"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374947-5.00022-5"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010006\u20100170\u20106"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006111218"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.06.004"},{"issue":"4","key":"e_1_2_12_90_1","article-title":"Decreased Phosphorylated CREB and AKT in Individuals With Autism Normalized After Zinc Therapy","volume":"5","author":"Russo A.","year":"2017","journal-title":"Academic Journal of Pediatrics and Neonatology"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1137"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07080.x"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2310"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2023.151292"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01946669"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300518"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114728"},{"key":"e_1_2_12_98_1","first-page":"8","article-title":"Emerging Neuroprotective Approaches in Stroke Treatment","volume":"4","author":"Sharma S. S.","year":"2003","journal-title":"Current Research & Information on Pharmaceutical Sciences"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.68.1.821"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.09.003"},{"key":"e_1_2_12_101_1","volume-title":"Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects","author":"Soueid J.","year":"2015"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092115"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)62956-X"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.00901"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4047.401"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00135-3"},{"key":"e_1_2_12_107_1","volume-title":"Food and Drug Administration Approval for Risperdal (Risperidone) in Treatment of the Irritability Associated With Autistic Disorder","author":"USFDA","year":"2006"},{"key":"e_1_2_12_108_1","volume-title":"Bristol Myers Squibb U.S. Food and Drug Administration Approves ABILIFY\u00ae (Aripiprazole) for the Treatment of Irritability Associated With Autistic Disorder in Pediatric Patients (Ages 6 to 17\u2009Years)","author":"USFDA","year":"2009"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065487"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-213016"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00255"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2022.0180"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S85717"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn987"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0074-1"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4805-4"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009851"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90399-9"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90375-5"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146366"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-023-01360-w"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.70049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:09:35Z","timestamp":1750820975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.70049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":120,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jnr.70049"],"URL":"https:\/\/doi.org\/10.1002\/jnr.70049","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.70049\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70049\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70049\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70049\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70049\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70049\/v2\/review1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70049"}}