{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:57Z","timestamp":1786988157891,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cerebellar ataxia is a debilitating neurodegenerative disorder characterized by impaired motor coordination and balance with limited treatment options. Abscisic acid (ABA), a phytohormone detected in mammalian brains, has shown neuroprotective properties. This study investigated the effects of ABA on motor, cognitive, and affective deficits in a mouse model of cerebellar ataxia in which male Swiss mice received a single intraperitoneal injection of 3\u2010acetylpyridine (3\u2010AP; 60\u2009mg\/kg), which leads to the loss of climbing fiber input to Purkinje neurons leading to cerebellar degeneration. In ABA\u2010treated groups, ABA (10 or 15\u2009\u03bcg\/mouse) was intracerebroventricularly applied for four consecutive days. Behavioral testing consisted of open field, footprint analysis, wire grip, rotarod, tail suspension, elevated plus maze, Morris water maze, and the passive avoidance assay. Cerebellar brain\u2010derived neurotrophic factor (BDNF) levels were measured using ELISA. As expected, 3\u2010AP\u2010treated mice exhibited significant motor impairments, increased anxiety\u2010like and depressive\u2010like behaviors, and cognitive deficits. ABA treatment, particularly at the 15\u2009\u03bcg\/mouse dose, significantly improved motor coordination, locomotor activity, memory, and spatial and passive avoidance learning as well as reduced anxiety\u2010like and depressive\u2010like behaviors. Behavioral changes were associated with normalization of the 3\u2010AP\u2010induced increases in cerebellar BDNF levels. This study demonstrates that ABA can ameliorate motor, cognitive, and affective deficits in a mouse model of cerebellar ataxia, which could involve BDNF and be due to neuroprotective effects in the cerebellum. By extension, our data suggest that ABA may have therapeutic potential in the management of cerebellar ataxia and other cerebellar disorders.<\/jats:p>","DOI":"10.1002\/jnr.70055","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:22:56Z","timestamp":1750051376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Abscisic Acid Enhances Motor and Cognitive Function in the 3\u2010Acetylpyridine Mouse Model of Cerebellar Ataxia"],"prefix":"10.1002","volume":"103","author":[{"given":"Monavareh","family":"Soti","sequence":"first","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Ilaghi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Calgary  Calgary, Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-3816","authenticated-orcid":false,"given":"Kristi A.","family":"Kohlmeier","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh","family":"Sabzalizadeh","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-5849","authenticated-orcid":false,"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2024.08.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.02.040"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.160077"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25610"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194113"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20170"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29750"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3574012"},{"key":"e_1_2_12_10_1","article-title":"Abscisic Acid Synthesis and Response","volume":"11","author":"Finkelstein R.","year":"2013","journal-title":"Arabidopsis Book\/American Society of Plant Biologists"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2023.152185"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964650"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrleng.2021.09.015"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020361"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102954"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.06.011"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10277"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.22410"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0653-2_21"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.234898"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25558"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228425"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2022.879634"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1634067"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.1155"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109365"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1403.009"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01141"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2022.11.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2023.2263911"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63916-5.00017-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-010-9137-7"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050523"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-015-0664-x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.089"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12030367"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.12.009"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu006"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-022-06415-6"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1451-23.2023"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0137-3"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.16.3.367"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.07.005"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8482-3"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.134"},{"issue":"5","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2564","article-title":"Phytohormone Abscisic Acid Elicits Positive Effects on Harmaline\u2010Induced Cognitive and Motor Disturbances in a Rat Model of Essential Tremor","volume":"12","author":"Shabani M.","year":"2022","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"issue":"12","key":"e_1_2_12_47_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2796","article-title":"Central Injection of Abscisic Acid Attenuates Mood Disorders Induced by Subchronic Stress in Male Mice","volume":"12","author":"Shabani M.","year":"2022","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.03.015"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18473"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7326"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.11.010"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00334.x"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10603.2002"},{"key":"e_1_2_12_54_1","article-title":"Modulation of Purkinje Cell Inhibition by Stem Cell Factor","author":"Zaman T.","year":"2024","journal-title":"bioRxiv"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7051"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:09:44Z","timestamp":1750820984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jnr.70055"],"URL":"https:\/\/doi.org\/10.1002\/jnr.70055","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.70055\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70055\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70055\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70055\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70055\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70055\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.70055\/v2\/review1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70055"}}