{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:34Z","timestamp":1772118754596,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012066","name":"Wings for Life","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001708","name":"International Foundation for Research in Paraplegia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Spinal cord injury (SCI) disrupts spinal tracts and neuronal pathways, including those in the primary motor cortex (M1) and the lumbar cord enlargement (LCE) involved in motor control. This study sought to determine whether metabolite concentrations deviate between SCI and healthy controls (HC) in M1 and LCE using proton magnetic resonance spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS) and structural MRI, and if these correlate with clinical impairment. Sixteen chronic SCI (mean age: 54.7\u2009\u00b1\u200914.8y) and 19 HCs (mean age: 53.2\u2009\u00b1\u200918.8y) underwent\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS to quantify metabolites along with T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010 and T\n                    <jats:sub>2<\/jats:sub>\n                    *\u2010weighted MRI to assess tissue structural changes. Associations between metabolic and structural changes and clinical impairment were also assessed. Patients showed significant atrophy in both white matter of the LCE (HC: 37.7\u2009\u00b1\u20094.7\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    , SCI: 33.9\u2009\u00b1\u20093.7\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    , \u0394\u2009=\u2009\u221210.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015) and gray matter (HC: 20.9\u2009\u00b1\u20092.1\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    , SCI: 19.4\u2009\u00b1\u20091.5\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    , \u0394\u2009=\u2009\u22127.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022). Total N\u2010acetylaspartate (tNAA) with respect to total creatine (tCr) was reduced in M1 of SCI (HC: 1.94\u2009\u00b1\u20090.21, SCI: 1.77\u2009\u00b1\u20090.14, \u2206\u2009=\u2009\u22128.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) and in the LCE (HC: 2.48\u2009\u00b1\u20090.76, SCI: 1.81\u2009\u00b1\u20090.80, \u2206\u2009=\u2009\u221227.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). In conclusion, reduced tNAA\/tCr in both the atrophied LCE and M1 suggests widespread neuronal changes including cell atrophy and\/or cell loss after injury. These findings provide in\u00a0vivo evidence for retrograde and trans\u2010synaptic neurodegeneration, which may underline the atrophy observed in the motor system in SCI. Ultimately, this highlights the potential for metabolic and structural biomarkers to improve the monitoring of subtle neurodegeneration following SCI and to enhance future regenerative treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/jnr.70071","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:35:17Z","timestamp":1753360517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In\u2010Vivo\n                    <scp>\n                      <sup>1<\/sup>\n                      H\n                    <\/scp>\n                    \u2010\n                    <scp>MR<\/scp>\n                    Spectroscopy Investigation"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3969-193X","authenticated-orcid":false,"given":"Simon","family":"Schading\u2010Sassenhausen","sequence":"first","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1908-4328","authenticated-orcid":false,"given":"Anna","family":"Lebret","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-7395","authenticated-orcid":false,"given":"Kadir","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre (CUBRIC) Cardiff University  Cardiff UK"},{"name":"School of Computer Science and Informatics Cardiff University  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-4974","authenticated-orcid":false,"given":"Pauline","family":"Gut","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-9344","authenticated-orcid":false,"given":"Sabrina","family":"Imhof","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-3359","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Z\u00f6rner","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital 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