{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:43:00Z","timestamp":1780328580345,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002336","name":"Daiichi Sankyo Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac sarcoidosis (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) is a noncaseating granulomatous disease of unknown etiology. Lifelong immunosuppressive therapy, most frequently using corticosteroids, is a standard therapy to control hypersensitivity of immune reactions and prevent inflammation. However, it sometimes causes various systemic adverse effects and requires dose escalation. Thus, additional therapy may be required for the treatment of this disease. Recently, <jats:italic>Propionibacterium acnes<\/jats:italic> (<jats:italic>P. acnes<\/jats:italic>) was reported as one of the etiologic agents of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>, indicating that antibacterial drugs (<jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content>) may be effective for the treatment of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>. The objective of this study was to investigate the effect of <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> treatment, in addition to standard corticosteroid therapy, in patients with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Japanese Antibacterial Drug Management for Cardiac Sarcoidosis (J\u2010<jats:styled-content style=\"fixed-case\">ACNES<\/jats:styled-content>) trial was designed as a prospective, multicenter, randomized, open\u2010label, controlled clinical trial. The patients will be randomized to receive either standard corticosteroid therapy plus <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> therapy (<jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> group) or standard corticosteroid therapy (standard group). The primary endpoint is change in the total standardized uptake value at 6 months vs baseline using fluorine\u201018 fluorodeoxyglucose positron emission tomography and computed tomography. Secondary endpoints include efficacy, prognosis, and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study are currently under investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The J\u2010<jats:styled-content style=\"fixed-case\">ACNES<\/jats:styled-content> trial will be the first prospective study assessing the clinical benefit and safety of <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> therapy, in addition to corticosteroid treatment, in patients with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>. Our findings may improve treatment of patients with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>, as additional <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> therapy reduces recurrence of inflammation and elucidates the mechanism of sarcoidosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12084","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T12:18:05Z","timestamp":1535717885000},"page":"520-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Japanese Antibacterial Drug Management for Cardiac Sarcoidosis (J\u2010<scp>ACNES<\/scp>): A multicenter, open\u2010label, randomized, controlled study"],"prefix":"10.1002","volume":"34","author":[{"given":"Kohei","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Eishi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurume University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Asakura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hyogo College of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naka","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Asahikawa Medical University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Okayama University Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Takaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Okayama University Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kurume University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Yazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Saku Central Hospital Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shinjuku Kaijo Bldg. 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