{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:17:58Z","timestamp":1787804278745,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Implantable cardioverter defibrillator (ICD) and cardiac resynchronization with a defibrillator (CRT\u2010D) are established therapies for secondary prevention of sudden cardiac death (SCD) in patients with structural heart disease (SHD), but the rates of subsequent ICD\/CRT\u2010D therapy widely differ among patients with SHD. The aim of this study was to determine clinical factors associated with appropriate therapy for preventing SCD in patients with SHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 147 patients with SHD (mean age, 59\u00a0\u00b1\u00a015\u00a0years; mean ejection fraction [EF], 45\u00a0\u00b1\u00a015%) who underwent ICD\/CRT\u2010D implantation for secondary prevention of SCD (ischemic heart disease, n\u00a0=\u00a050; nonischemic heart disease, n\u00a0=\u00a097). ICD\/CRT\u2010D was implanted for aborted cardiopulmonary arrest (CPA, n\u00a0=\u00a065) or sustained ventricular tachycardia (VT, n\u00a0=\u00a082).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a follow\u2010up period of 3.2\u00a0\u00b1\u00a03.6\u00a0years, 79 of the 147 patients had appropriate ICD\/CRT\u2010D therapies. A Kaplan\u2010Meier survival curve showed that the rate of appropriate therapy was 54% at 5\u2010year follow\u2010up. Prior sustained VT, lower EF, and use of a class I antiarrhythmic drug were significantly more frequent in patients with appropriate therapy. In multivariate analysis, prior sustained VT (hazard ratio, 2.8; 95% CI, 1.60\u20104.46;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) was the only independent predictor for appropriate ICD\/CRT\u2010D therapy. Kaplan\u2010Meier survival curves showed that rates of appropriate therapy during a 5\u2010year follow\u2010up period were 70% and 34% in patients with sustained VT and those with CPA, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In SHD patients implanted with an ICD\/CRT\u2010D, prior sustained VT as an indication of ICD\/CRT\u2010D implantation, but not EF or an antiarrhythmic drug, predicts a high rate of appropriate therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.12086","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T11:45:18Z","timestamp":1534938318000},"page":"527-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of appropriate ICD therapy in Japanese patients with structural heart diseases: A major role of prior sustained ventricular tachycardia in secondary prevention"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-9470","authenticated-orcid":false,"given":"Daigo","family":"Nagahara","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Fujito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine 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Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo 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arrhythmias detected after transvenous defibrillator implantation in patients with a clinical history of only ventricular fibrillation. 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