{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:35:16Z","timestamp":1787960116562,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Supraventricular arrhythmias are common in Brugada syndrome (<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>), and notoriously difficult to manage with medical therapy secondary to associated risks. Pulmonary vein isolation (<jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>) is often utilized instead, but its outcomes in this population are not well\u2010known. We aim to provide a holistic evaluation of interventional treatment for Atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) in the <jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content> population. Electronic databases Medline, Embase, Cinahl, Cochrane, and Scopus were systematically searched for publications between 01\/01\/1995 and 12\/31\/2017. Studies were screened based on predefined inclusion and exclusion criteria. A total of 49 patients with <jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> were included. Age range from 28.8 to 64 years, and 77.5% were male. 38 patients were implanted with implantable cardioverter\u2010defibrillators (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>) at baseline, and of them, 39% suffered inappropriate shocks for rapid <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. 34\/49 (69%) of patients achieved remission following a single <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> procedure. Of the remaining, 13 patients underwent one or more repeat ablation procedures. Overall, 45\/49 (91.8%) of patients remained in remission during long\u2010term follow\u2010up after one or more <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> procedures in the absence of antiarrhythmic drug (<jats:styled-content style=\"fixed-case\">AAD<\/jats:styled-content>) therapy. Postablation, no patients suffered inappropriate <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> shock. Furthermore, no major complications secondary to <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> occurred in any patient. <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> ablation achieves acute and long\u2010term success in the vast majority of patients. It is effective in preventing inappropriate <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> therapy secondary to rapid <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. Complication rates of <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content> are low. Thus, in light of the risks of <jats:styled-content style=\"fixed-case\">AAD<\/jats:styled-content>s and risk of inappropriate <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> shocks in the <jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content> population, catheter ablation could represent an appropriate first\u2010line therapy for paroxysmal atrial fibrillation in <jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1002\/joa3.12113","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T11:05:46Z","timestamp":1535972746000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ablation of atrial fibrillation in patients with Brugada syndrome: A systematic review of the 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