{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T01:01:27Z","timestamp":1773190887791,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Risk stratification in patients with asymptomatic Brugada Syndrome is challenging, and despite recent advances, there is no clear evidence. The first\u2010degree atrioventricular block was hypothesized to be a predictor of arrhythmic events. Measurement of the PR interval and diagnosing atrioventricular block from surface ECG is easy, noninvasive, and cost\u2010effective. We aimed to assess the latest evidence on PR interval or first\u2010degree atrioventricular block and major arrhythmic events related to Brugada Syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a comprehensive search in PubMed for \u201catrioventricular block\u201d OR \u201cPR interval\u201d and \u201cBrugada syndrome.\u201d We included studies that have a component of PR interval and\/or first\u2010degree atrioventricular block and major arrhythmic events related to Brugada Syndrome including syncope\/VT\/VF\/appropriate ICD shocks\/ICD implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1526 subjects from 7 studies. Pooled mean difference of PR interval in 4 studies showed a significant difference [MD 10.77\u00a0ms (2.97\u201018.57) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007, moderate\u2010high heterogeneity I<jats:sup>2<\/jats:sup>\u00a0=\u00a053% <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08]. On sensitivity analysis by removing a study, it became MD 6.50\u00a0ms [1.97\u201011.03], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005, heterogeneity I<jats:sup>2<\/jats:sup>\u00a0=\u00a00% <jats:italic>P<\/jats:italic>\u00a0=\u00a00.52. Indicating that PR interval was prolonged by small margin. Pooled analysis of the association between a first\u2010degree atrioventricular block and major arrhythmic events was significant [OR 3.33 (2.02\u20105.50) <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, low heterogeneity I<jats:sup>2<\/jats:sup>\u00a0=\u00a00% <jats:italic>P<\/jats:italic>\u00a0=\u00a00.57].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First\u2010degree AV block is associated with more frequent major arrhythmic events in Brugada syndrome patients. PR interval seemed to be prolonged but is yet to be determined whether the PR interval association is still significant if it did not cross the first\u2010degree AVB threshold.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12188","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T13:05:33Z","timestamp":1557839133000},"page":"584-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between PR Interval, First\u2010degree atrioventricular block and major arrhythmic events in patients with Brugada syndrome \u2013 Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-6551","authenticated-orcid":false,"given":"Raymond","family":"Pranata","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universitas Pelita Harapan Tangerang Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-405X","authenticated-orcid":false,"given":"Emir","family":"Yonas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas YARSI Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-1108","authenticated-orcid":false,"given":"Veresa","family":"Chintya","sequence":"additional","affiliation":[{"name":"Sanjiwani General Hospital Bali Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadrian","family":"Deka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Gadjah Mada Jogjakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-8231","authenticated-orcid":false,"given":"Sunu Budhi","family":"Raharjo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine Universitas Indonesia National Cardiovascular Center Harapan Kita Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.5.666"},{"issue":"13","key":"e_1_2_9_4_1","first-page":"e210","article-title":"2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary","volume":"138","author":"Al\u2010Khatib SM","year":"2018","journal-title":"Circulation"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut272"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.06.033"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"First\u2010degree atrioventricular block on basal electrocardiogram predicts future arrhythmic events in patients with Brugada syndrome: a long\u2010term follow\u2010up study from the Veneto region of Northeastern Italy","volume":"21","author":"Migliore F","year":"2018","journal-title":"EP Eur"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13349"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.52.98"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.05.056"},{"issue":"11","key":"e_1_2_9_11_1","first-page":"1864","article-title":"Brugada syndrome in the young: an assessment of risk factors predicting future events","volume":"19","author":"Gonzalez Corcia MC","year":"2017","journal-title":"Europace"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01050.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12589"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12097"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027983"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12507"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJCA.IJCA_31_18"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/joa3.12188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T20:08:29Z","timestamp":1694290109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/joa3.12188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/joa3.12188"],"URL":"https:\/\/doi.org\/10.1002\/joa3.12188","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"value":"1880-4276","type":"print"},{"value":"1883-2148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"2019-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}