{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:08:24Z","timestamp":1762272504098,"version":"3.40.5"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brugada syndrome (BrS) is an inherited arrhythmic disease associated with an increased risk of major arrhythmic events (MAE). Previous studies reported that a wide QRS complex may be useful as a predictor of MAE in BrS patients. We aimed to assess the correlation of wide QRS complex with MAE by a systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We comprehensively searched the databases of MEDLINE and EMBASE from inception to June 2019. Included studies were cohort and case control studies that reported QRS duration and the relationship between wide QRS complex (&gt;120\u00a0milliseconds) and MAE (sudden cardiac death, sudden cardiac arrest, ventricular fibrillation, sustained ventricular tachycardia, or appropriate shock). Data from each study were combined using the random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two studies from 2007 to 2018 were included in this meta\u2010analysis involving 4,814 BrS patients. The mean age was 46.1\u00a0\u00b1\u00a012.8\u00a0years. The patients were predominately men (77.6%). Wide QRS duration was an independent predictor of MAE (pooled risk ratio 1.55, 95% confidence interval: 1.04\u20102.30, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.30, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a038.4%). QRS duration was wider in BrS who had history of MAE (weight mean difference\u00a0=\u00a08.12\u00a0milliseconds, 95% confidence interval: 5.75\u201010.51\u00a0milliseconds).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that QRS duration is wider in BrS who had history of MAE, and a wide QRS complex is associated with 1.55 times higher risk of MAE in BrS populations. Wide QRS complex can be considered for risk stratification in prediction of MAE in patients with BrS, especially when considering implantable cardioverter\u2010defibrillator placement in asymptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12290","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T08:53:13Z","timestamp":1577436793000},"page":"143-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Wide QRS complex and the risk of major arrhythmic events in Brugada syndrome patients: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-5854","authenticated-orcid":false,"given":"Pattara","family":"Rattanawong","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix AZ USA"},{"name":"Faculty of Medicine Ramathibodi Hospital Mahidol University 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