{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:25:07Z","timestamp":1747149907357,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frequent ventricular premature depolarizations (VPDs) can cause reversible cardiomyopathy (CMP). However, many patients maintain a normal left ventricular (LV) function with a high VPD burden. The electrocardiographic characteristics of VPD\u2010induced CMP have not been elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and eighty (91 men, age; 51\u00a0\u00b1\u00a015\u00a0years) patients with frequent idiopathic VPDs (&gt;10% VPDs\/day or &gt;10\u00a0000 VPDs\/day) were studied. All patients underwent successful ablation and were then divided into two groups according to the echocardiographic findings before and after the ablation procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group A (n\u00a0=\u00a0139) had a normal LV function with VPD frequencies, and Group B (n\u00a0=\u00a041) had reversible LV dysfunction after ablation. The VPD QRS duration (QRSd) was wider in patients with CMP (Group A vs Group B; 137.2\u00a0\u00b1\u00a012.0\u00a0milliseconds vs 159.7\u00a0\u00b1\u00a05.3\u00a0milliseconds, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). VPDs with a terminal QRS delay marked by a notch followed by a discrete lower amplitude signal after the peak R wave in any precordial lead were identified. The incidence of terminal signals was higher in the CMP group (Group A vs Group B; 2.1% vs 53.6%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The wider VPD QRSd and terminal QRS delay in patients with VPD\u2010induced CMP suggest subclinical cell\u2010to\u2010cell conduction abnormalities as a potential factor predisposing VPD\u2010induced CMP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12324","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T09:04:56Z","timestamp":1583399096000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrocardiographic features of the presence of occult myocardial disease in patients with VPD\u2010induced cardiomyopathy"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2544-2422","authenticated-orcid":false,"given":"Sung Il","family":"Im","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Kosin University Gospel Hospital Kosin University College of Medicine Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Bin","family":"Gwag","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-7283","authenticated-orcid":false,"given":"Young Keun","family":"On","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-9691","authenticated-orcid":false,"given":"Kyoung\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of 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