{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:34:21Z","timestamp":1772757261043,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T00:00:00Z","timestamp":1584230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiac resynchronization therapy (CRT) is a device\u2010based method of treatment which decreases morbidity and mortality in heart failure with reduced ejection fraction (HFrEF). This study was aimed to investigate the effects of CRT on hemodynamic and arterial stiffness parameters evaluated by noninvasive method, and determine whether there is a correlation between the changes after CRT in these parameters and the clinical response to CRT or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 46 patients with HFrEF who were planned to undergo CRT implantation. Before the CRT implantation, clinical and demographic data were recorded from all patients. Hemodynamic and arterial stiffness parameters were measured oscillometrically by an arteriograph before CRT implantation. The patients were re\u2010evaluated minimum three months after CRT; the above\u2010mentioned parameters were measured again and compared to the pre\u2010CRT period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the period before CRT, mean systolic blood pressure (SBP) (116.8\u00a0\u00b1\u00a019.1\u00a0mm Hg vs 127.7\u00a0\u00b1\u00a020.9\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), central SBP (cSBP) (106.2\u00a0\u00b1\u00a017.3\u00a0mm Hg vs 116.8\u00a0\u00b1\u00a018.7\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015), cardiac output (CO) (4.6\u00a0\u00b1\u00a00.8 lt\/min vs 5.1\u00a0\u00b1\u00a00.8 lt\/min, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), stroke volume (65.6\u00a0\u00b1\u00a016.3\u00a0mL vs 72.0\u00a0\u00b1\u00a014.9\u00a0mL), and pulse wave velocity (PWV) (10\u00a0\u00b1\u00a01.6\u00a0m\/sec vs 10.4\u00a0\u00b1\u00a01.8\u00a0m\/sec, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) increased significantly in post\u2010CRT period. In addition, the same parameters were significantly increased post\u2010CRT period in patients with clinical response. However, there was not any similar increase in nonresponder patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that SBP, CO, and PWV increased significantly after CRT. The modest increases in these parameters were observed to be associated with positive clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12331","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T04:29:06Z","timestamp":1584332946000},"page":"498-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of cardiac resynchronization therapy on arterial stiffness and central hemodynamic parameters"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6907-6941","authenticated-orcid":false,"given":"Metin","family":"Coksevim","sequence":"first","affiliation":[{"name":"School of Medicine Department of Cardiology Ondokuz Mayis University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Akcay","sequence":"additional","affiliation":[{"name":"School of Medicine Department of Cardiology Ondokuz 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okan","family":"Gulel","sequence":"additional","affiliation":[{"name":"School of Medicine Department of Cardiology Ondokuz Mayis University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Sahin","sequence":"additional","affiliation":[{"name":"School of Medicine Department of Cardiology Ondokuz Mayis University Samsun 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