{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:25:16Z","timestamp":1747149916110,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) often co\u2010exists with renal function (RF) impairment. We investigated the characteristics and management of AF patients across creatinine clearance strata and potential changes in the use of nonvitamin K oral anticoagulants (NOAC) according to different equations for estimation of RF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this post hoc analysis of the BALKAN\u2010AF survey, patients were classified according to RF (Cockcroft\u2010Gault formula) as: preserved\/mildly depressed RF (P\u2010RF) \u226550\u00a0mL\/min, moderately depressed RF (MD\u2010RF) 30\u201049\u00a0mL\/min, and severely depressed RF (SD\u2010RF) &lt;30\u00a0mL\/min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2712 enrolled patients, 2062 (76.0%) had data on RF. Patients with SD\u2010RF and MD\u2010RF were older, had higher mean value of European Heart Rhythm Association score, stroke and bleeding risk scores, and more comorbidities than patients with P\u2010RF (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). They received oral anticoagulants (OAC), AF catheter ablation, and electrical cardioversion less often than those with P\u2010RF (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Rate control, no OAC, single\u2010antiplatelet therapy (SAPT) alone, and loop diuretics were more prevalent in patients with SD\u2010RF and MD\u2010RF than in subjects with P\u2010RF (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.005). An important change in NOAC therapy could appear in &lt;1% of patients (Modification of Diet in Renal Disease formula) and in &lt;1% of patients (Chronic Kidney Disease Epidemiology Collaboration group formula).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with SD\u2010RF and MD\u2010RF were older, more symptomatic, had higher stroke and bleeding risk and more comorbidities than those with P\u2010RF. They were less likely to receive OAC and more likely to use rate control strategy, SAPT alone, and no OAC than subjects with P\u2010RF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12404","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T06:46:14Z","timestamp":1595227574000},"page":"863-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment implications of renal disease in patients with atrial fibrillation: The BALKAN\u2010AF survey"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-1975","authenticated-orcid":false,"given":"Monika","family":"Kozie\u0142","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"1st Department of Cardiology and Angiology Silesian Centre for Heart Diseases Zabrze Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Simovic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic University Clinical Center of Kragujevac Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Clinical Center Sestre Milosrdnice Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Nedeljkovic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic Clinical Center of Serbia Belgrade Serbia"},{"name":"School of Medicine Belgrade University Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Kocijancic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Paparisto","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology University Hospital Center Mother Theresa Tirana Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljilja","family":"Music","sequence":"additional","affiliation":[{"name":"Cardiology Clinic University Clinical Center of Montenegro University of Podgorica Medical Faculty Podgorica Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Trendafilova","sequence":"additional","affiliation":[{"name":"Coronary Care Unit National Heart Hospital Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-0596","authenticated-orcid":false,"given":"Anca Rodica","family":"Dan","sequence":"additional","affiliation":[{"name":"Cardiology Department Colentina University Hospital Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sime","family":"Manola","sequence":"additional","affiliation":[{"name":"Clinical Center Sestre Milosrdnice Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zumreta","family":"Kusljugic","sequence":"additional","affiliation":[{"name":"Cardiology Department Clinic of Internal Medicine Medical Faculty University Clinical Center Tuzla Tuzla Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe\u2010Andrei","family":"Dan","sequence":"additional","affiliation":[{"name":"Medicine University \"Carol Davila\" Colentina University Hospital Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"1st Department of Cardiology and Angiology Silesian Centre for Heart Diseases Zabrze Poland"},{"name":"School of Medicine Belgrade University Belgrade Serbia"},{"name":"Aalborg Thrombosis Research Unit Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana S.","family":"Potpara","sequence":"additional","affiliation":[{"name":"Cardiology Clinic Clinical Center of Serbia Belgrade Serbia"},{"name":"School of Medicine Belgrade University Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the BALKAN\u2010AF Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv202"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.04.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60178-5"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"1","article-title":"Kidney disease: improving global outcomes (KDIGO) CKD work group. 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