{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:17:47Z","timestamp":1767136667824,"version":"build-2238731810"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T00:00:00Z","timestamp":1596326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although some post myocardial infarction (post\u2010MI) and dilated cardiomyopathy (DCM) patients with mid\u2010range ejection fraction heart failure (HFmrEF\/40%\u201049%) face an increased risk for arrhythmic sudden cardiac death (SCD), current guidelines do not recommend an implantable cardiac defibrilator (ICD). We risk stratified hospitalized HFmrEF patients for SCD with a combined non\u2010invasive risk factors (NIRFs) guiding to programmed ventricular stimulation (PVS) two\u2010step approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight patients (male\u00a0=\u00a083%, age\u00a0=\u00a064\u00a0\u00b1\u00a014\u00a0years, LVEF\u00a0=\u00a045\u00a0\u00b1\u00a05%, CAD\u00a0=\u00a069%, DCM\u00a0=\u00a031%) underwent a NIRFs screening first\u2010step with electrocardiogram (ECG), SAECG, Echocardiography and 24\u2010hour ambulatory ECG (AECG). Thirty\u2010two patients with presence of one of three NIRFs (SAECG\u00a0\u2265\u00a02 positive criteria for late potentials, ventricular premature beats\u00a0\u2265\u00a0240\/24\u00a0hours, and non\u2010sustained ventricular tachycardia [VT] episode\u00a0\u2265\u00a01\/24\u00a0hours) were further investigated with PVS. Patients were classified as either low risk (Group 1, n\u00a0=\u00a016, NIRFs\u2212), moderate risk (Group 2, n\u00a0=\u00a018, NIRFs+\/PVS\u2212), and high risk (Group 3, n\u00a0=\u00a014, NIRFs+\/PVS+). All in Group 3 received an ICD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 41\u00a0\u00b1\u00a018\u00a0months, 9 of 48 patients, experienced the major arrhythmic event (MAE) endpoint (clinical VT\/fibrillation\u00a0=\u00a03, appropriate ICD activation\u00a0=\u00a06). The endpoint occurred more frequently in Group 3 (7\/14, 50%) than in Groups 1 and 2 (2\/34, 5.8%). Logistic regression model adjusted for PVS, age, and LVEF revealed that PVS was an independent MAE predictor (OR: 21.152, 95% CI: 2.618\u2010170.887,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). Kaplan\u2010Meier curves diverged significantly (log rank,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) while PVS negative predictive value was 94%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In hospitalized HFmrEF post\u2010MI and DCM patients, a NIRFs guiding to PVS two\u2010step approach efficiently detected the subgroup at increased risk for MAE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.12416","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T02:03:36Z","timestamp":1596420216000},"page":"890-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Arrhythmic risk stratification in heart failure mid\u2010range ejection fraction patients with a non\u2010invasive guiding to programmed ventricular stimulation two\u2010step approach"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-8407","authenticated-orcid":false,"given":"Petros","family":"Arsenos","sequence":"first","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"},{"name":"Arsenos Heart and Biosignals Lab Avlonas Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-0303","authenticated-orcid":false,"given":"Konstantinos A.","family":"Gatzoulis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Doundoulakis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polychronis","family":"Dilaveris","sequence":"additional","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-2404","authenticated-orcid":false,"given":"Christos\u2010Konstantinos","family":"Antoniou","sequence":"additional","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soulaidopoulos","family":"Stergios","sequence":"additional","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skevos","family":"Sideris","sequence":"additional","affiliation":[{"name":"State Department of Cardiology Hippokration General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotiropoulos","family":"Ilias","sequence":"additional","affiliation":[{"name":"State Department of Cardiology Hippokration General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Tousoulis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology and Electrophysiology Laboratory Hippokration General Hospital National and Kapodistrian University of Athens School of Medicine Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.4296"},{"issue":"5","key":"e_1_2_8_4_1","first-page":"e204296","article-title":"Risk stratification for sudden cardiac death in heart failure population. 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