{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:45:31Z","timestamp":1793083531323,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R21HL140432 (YK)"],"award-info":[{"award-number":["R21HL140432 (YK)"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sleep apnea is highly prevalent in patients with atrial fibrillation (AF). Obstructive sleep apnea (OSA) is the most common type, and best studied in the context of AF. However, recent investigations have indicated that central sleep apnea (CSA) may be a risk factor for incident AF. We evaluated the burden of CSA events in patients referred for diagnostic polysomnography (PSG) and whether AF is associated with CSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified patients with and without a history of AF who underwent clinically indicated PSG in a matched manner. OSA was defined as obstructive apnea\u2010hypopnea index (AHI) \u226515\/h, and CSA was defined as central apnea index (CAI) \u22655\/h. The association between AF and CSA was evaluated using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 465 patients included, mean AHI was 25.5\/h, and mean CAI was 1.7\/h. OSA prevalence was 53.3%, while CSA prevalence was 8.4%. The prevalence of OSA in the AF and non\u2010AF groups (54.7% vs 52.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.56) was similar. CSA was more common in the AF group (12.3% vs 4.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002). In multivariable analysis, AF (OR: 2.19 [1.02, 5.03],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05), male gender (OR: 2.5 [1.17, 5.84],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02), and older age (OR: 2.44, [1.16, 5.46],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02) were associated with CSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Though CSA is much less common than OSA in patients with AF, the presence of AF is independently associated with CSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.12427","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T01:37:32Z","timestamp":1599183452000},"page":"991-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Atrial fibrillation is associated with central sleep apnea in clinic patients undergoing diagnostic polysomnography"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-1544","authenticated-orcid":false,"given":"Evan Kenneth","family":"Harmon","sequence":"first","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeilim","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sula","family":"Mazimba","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Bilchick","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Preventative Medicine Northwestern University Chicago IL USA"},{"name":"Department of Medicine Hualien Armed Forces General Hospital Hualien Taiwan"},{"name":"Department of Medicine Tri\u2010Service General Hospital and National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Aliasghar Gharib","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishesh K.","family":"Kapur","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younghoon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Health System Charlottesville VA USA"},{"name":"Division of Pulmonary Critical Care and Sleep Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"195","article-title":"Atrial fibrillation: the current epidemic","volume":"14","author":"Morillo CA","year":"2017","journal-title":"J Geriatr Cardiol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.08.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2019.100447"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206655"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1442OC"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000068337.25994.21"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.08.046"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-018-0489-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.103"},{"issue":"5","key":"e_1_2_8_11_1","first-page":"930","article-title":"Central sleep apnoea\u2010a clinical review","volume":"7","author":"Muza RT","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1449ED"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13665-019-0221-z"},{"key":"e_1_2_8_14_1","first-page":"633","article-title":"Complex sleep apnea syndrome","volume":"7","author":"Wang J","year":"2013","journal-title":"Patient Prefer Adherence"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004500"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1523OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12639"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4022\/jafib.2031"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2020.100527"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9706079"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.9911064"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.12.1543"},{"issue":"1","key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cphy.c110057","article-title":"Central sleep apnea","volume":"3","author":"Javaheri S","year":"2013","journal-title":"Compr Physiol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft066"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506459"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.08.003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2434"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5962"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1695"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12927"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.02.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0859-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1488"},{"issue":"2","key":"e_1_2_8_36_1","first-page":"193","article-title":"Dysfunction of the autonomic nervous system in atrial fibrillation","volume":"7","author":"Xi Y","year":"2015","journal-title":"J Thorac Dis"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/joa3.12427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T03:25:10Z","timestamp":1693625110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/joa3.12427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/joa3.12427"],"URL":"https:\/\/doi.org\/10.1002\/joa3.12427","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"value":"1880-4276","type":"print"},{"value":"1883-2148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"assertion":[{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}