{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:34:30Z","timestamp":1775021670699,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catheter ablation (CA) for atrial fibrillation (AF) is widely performed. However, the indication for CA in patients with asymptomatic persistent AF is still controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 259 consecutive patients who were hospitalized for initial CA of AF, a total of 45 patients who had asymptomatic persistent AF were retrospectively analyzed. Quality of life (QOL) before and 1\u00a0year after CA was evaluated, and changes in the cardiac function over 5\u00a0years after CA were also examined. QOL was assessed using the AF QOL questionnaire (AFQLQ) developed by the Japanese Heart Rhythm Society. In addition, cardiac function was assessed by measuring the plasma B\u2010type natriuretic peptide (BNP) level, left ventricular ejection fraction (LVEF), left atrial diameter (LAD) with transthoracic echocardiogram, and left atrial (LA) volume with computed tomography (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AFQLQ significantly improved after CA in terms of \u201csymptom frequency\u201d and \u201cactivity limits and mental anxiety.\u201d The plasma BNP level, LVEF, and LAD significantly improved in the first 3\u00a0months after the first CA, with no significant changes thereafter (from 149.0\u00a0pg\/dL [95% confidence intervals {CI}, 114.5\u2010183.5\u00a0pg\/dL] to 49.8\u00a0pg\/dL [95% CI, 26.5\u201070.1], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001; from 60.8% [95% CI, 58.1%\u201363.6%] to 65.0% [95% CI, 62.6\u201067.4], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001; and from 41.3\u00a0mm [95% CI, 39.7\u201042.9] to 36.8 [95% CI, 34.5\u201039.1\u00a0mm], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001, respectively). LA volume revealed LA reverse remodeling after CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Improvement in the QOL and cardiac function after CA of asymptomatic persistent AF was revealed. Asymptomatic persistent AF should be appropriately treated by CA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12457","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T05:07:04Z","timestamp":1607749624000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Improvement in quality of life and cardiac function after catheter ablation for asymptomatic persistent atrial fibrillation"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-0285","authenticated-orcid":false,"given":"Naoaki","family":"Onishi","sequence":"first","affiliation":[{"name":"Division of Cardiology Tenri Hospital Tenri Japan"},{"name":"Japanese Red Cross Otsu Hospital Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shokan","family":"Kyo","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Otsu Hospital Otsu 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