{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:31:39Z","timestamp":1783650699072,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to clarify the current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced left ventricular ejection fraction (LVEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The follow\u2010up data of the Japan cardiac device treatment registry (JCDTR) was analyzed in 746 patients with LVEF \u226635% and no prior history of sustained ventricular arrhythmias who underwent de novo implantable cardioverter\u2010defibrillator (ICD) or cardiac resynchronization therapy with a defibrillator (CRT\u2010D) implantation between January 2011 and August 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Electrophysiological study (EPS) with programmed ventricular stimulation had been performed before the device implant in 118 patients (15.8%, EPS group). During the mean follow\u2010up of 21\u00a0\u00b1\u00a012\u00a0months, the rate of freedom from any death and appropriate defibrillator therapy was not significantly different between EPS group (n\u00a0=\u00a0118) and No EPS group (n\u00a0=\u00a0628). NYHA class II\u2010IV, and QRS duration were negatively associated with performing EPS. Among patients in the EPS group, the rate of ventricular tachycardia (VT)\/ventricular fibrillation (VF) induction was 48%. The inducibility was not a predictor of appropriate defibrillator therapy, whereas BNP \u2267535\u00a0pg\/mL and no use of amiodarone were significantly associated with a risk of the appropriate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EPS for induction of VT\/VF had been performed in about 16% of patients with reduced LVEF before primary prevention ICD\/CRT\u2010D implantation. Elevated BNP levels and no use of amiodarone, but not inducibility of VT\/VF, appeared to be associated with appropriate defibrillator therapy in these populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12468","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T06:21:38Z","timestamp":1606630898000},"page":"148-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Current status and role of programmed ventricular stimulation in patients without sustained ventricular arrhythmias and reduced ejection fraction: Analysis of the Japan cardiac device treatment registry database"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-2148","authenticated-orcid":false,"given":"Hisashi","family":"Yokoshiki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"UBE Kohsan Central Hospital Upe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hoshi General Hospital Koriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kabutoya","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yoshiga","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine and Clinical Science Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Heart Rhythm Management University of Occupational &amp; 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