{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:25:26Z","timestamp":1747149926193,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elderly patients having a permanent pacemaker frequently have atrial remodeling. We examined the association between routine biomarkers and atrial fibrillation (AF) in patients receiving a dual\u2010chamber pacemaker for sinus node disease (SND) or second\u2010\/third\u2010degree atrioventricular block.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recorded clinical, laboratory, and electrocardiographic parameters as well as pacemaker lead parameters at implantation. The final analysis included 217 patients with SND and 393 patients with atrioventricular block. Notably, 102\/217 (47%) of the SND patients (median age: 77\u00a0years, 54% men) and 54\/393 (14%) of the atrioventricular block patients (median age: 79\u00a0years, 54% men) had AF history (paroxysmal or persistent).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariable analysis showed that red blood cell distribution width (RDW) (OR: 1.17; 95% CI: 1.05\u20101.36; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05) and serum \u03b3\u2010glutamyl transferase (\u03b3GT) levels (OR: 1.15; 95% CI: 1.03\u20101.28; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) were independently associated with AF history in patients with SND. In ROC curve analysis, the area under the curve (AUC) was 0.648; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01 for RDW, and 0.753; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01 for \u03b3GT. A RDW cut\u2010off point of 14 was associated with AF with a sensitivity of 67% and a specificity of 68%, while a \u03b3GT cut\u2010off point of 21 was associated with AF with a sensitivity of 80% and a specificity of 65%. In patients with second\u2010\/third\u2010degree atrioventricular block, there were no significant independent correlations between AF and the parameters studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In elderly patients with SND, RDW and \u03b3GT have an independent association with AF history. Our study failed to show any corresponding associations in patients with advanced disorders of atrioventricular conduction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12479","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T11:20:12Z","timestamp":1608290412000},"page":"219-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between routine biomarkers and atrial fibrillation in patients undergoing implantation of a dual\u2010chamber pacemaker"],"prefix":"10.1002","volume":"37","author":[{"given":"Konstantinos","family":"Kyrlas","sequence":"first","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School Ioannina 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Cardiology University of Ioannina Medical School Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Liberopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine University of Ioannina Medical School Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haralampos","family":"Milionis","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University of Ioannina Medical School Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-3593","authenticated-orcid":false,"given":"Panagiotis","family":"Korantzopoulos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School Ioannina 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