{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:59:41Z","timestamp":1768402781317,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor lysis syndrome (TLS) is a life\u2010threatening oncologic emergency associated with fatal complications including arrhythmia. The epidemiology and mortality outcomes of arrhythmia in TLS are scarcely studied in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the National Inpatient Sample (NIS) to study the prevalence and outcome of arrhythmia in patients hospitalized with TLS (ICD\u20109 code 277.88) from 2009 to 2014. Baseline characteristics, burden of arrhythmia, and pertinent outcomes were analyzed. Multivariable regression analysis was performed to identify the impact of underlying malignancy in predicting TLS\u2010related mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9034 cases of arrhythmia among 37\u00a0861 TLS patients were identified. More than half of the arrhythmia cases (67%) were found among white old (&gt;65) males admitted to large bed size and urban teaching hospitals. Arrhythmic cohort showed higher frequency of comorbidities such as fluid\u2010electrolyte disturbances, hypertension, congestive heart failure, renal failure, dyslipidemia, diabetes, pulmonary circulatory disorders, chronic pulmonary disease, coagulopathy, and deficiency anemia. The most common malignancies were leukemia, lymphoma, metastatic tumor, and solid tumor without metastasis. We found significantly higher odds of in\u2010hospital mortality among patients with TLS compared to general inpatient population on unadjusted (OR 9.69, 95% CI: 9.27\u201010.13, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and adjusted (OR 4.62, 95% CI: 4.39\u20104.85) multivariable analyses. Overall in\u2010hospital mortality (32% vs 21.3%), median length of stay (11\u00a0days vs 9\u00a0days), and hospital charges were higher among arrhythmic than nonarrhythmic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With the availability of more advanced cancer therapy in the US, nearly one in four inpatient encounters of TLS had arrhythmia. Arrhythmia in TLS patients was associated with higher odds of mortality and increased resource utilization. Therefore, strategies to improve the supportive care of TLS patients plus timely diagnosis and treatment of arrhythmia are of utmost importance in reducing mortality and health\u2010care cost.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12482","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T16:46:23Z","timestamp":1608309983000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Arrhythmia in tumor lysis syndrome and associated in\u2010hospital mortality: A nationwide inpatient analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Kishorbhai","family":"Gangani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Texas Health Arlington Memorial Hospital Arlington TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-2533","authenticated-orcid":false,"given":"Hee K.","family":"Fong","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine UC Davis Medical Center Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Faisaluddin","sequence":"additional","affiliation":[{"name":"Department of Medicine Deccan College of Medical Sciences Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad U.","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eastern Idaho Regional Medical Center Idaho Falls ID USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritika","family":"Manaktala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Canton Medical Education Foundation Canton OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Sadolikar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Creighton University School of Medicine AZ Health Alliance Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vraj","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical College Baroda Vadodara Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Medicine C. 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