{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:40:46Z","timestamp":1776400846559,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies indicate that uninterrupted anticoagulation (UA) is superior to interrupted anticoagulation (IA) in the periprocedural period during catheter ablation of atrial fibrillation. Still IA is followed in many centers considering the bleeding risk. This meta\u2010analysis compares interrupted and uninterrupted direct oral anticoagulation during catheter ablation of atrial fibrillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search into PubMed, EMBASE, and the Cochrane databases was performed and five studies were selected that directly compared IA vs UA before ablation and reported procedural outcomes, embolic, and bleeding events. The primary outcome of the study was major adverse cerebro\u2010cardiovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis included 840 patients with UA and 938 patients with IA. Median follow\u2010up was 30\u00a0days. Activated clotting time (ACT) before first heparin bolus was significantly longer with UA (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.006), whereas mean ACT was similar between the two groups (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.19). Total heparin dose needed was significantly higher with IA (mean, \u20121.61; 95% CI, \u20122.67 to \u20120.55; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.003). Mean procedure time did not vary between groups (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.81). Overall complication rates were low, with similar major adverse cerebro\u2010cardiovascular event (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.40) and total bleeding (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.55) rates between groups. Silent cerebral events (SCEs) were significantly more frequent with IA (log odds ratio, \u20120.90; 95% CI, \u20121.59 to \u20120.22; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>, 33%). Rates of major bleeding, minor bleeding, pericardial effusion, cardiac tamponade, and puncture complications were similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>UA during atrial fibrillation ablation has similar bleeding event rates, procedural times, and mean ACTs as IA, with fewer SCEs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12507","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T10:00:46Z","timestamp":1611914446000},"page":"384-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcomes of uninterrupted vs interrupted Periprocedural direct oral Anticoagulants in atrial Fibrillation ablation: A meta\u2010analysis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-0588","authenticated-orcid":false,"given":"Indranill","family":"Basu\u2010Ray","sequence":"first","affiliation":[{"name":"Department of Cardiology Memphis VA Medical Center Memphis TN USA"},{"name":"The University of Tennessee Health Science Center Memphis TN USA"},{"name":"All India Institute of Medical Sciences Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dibbendhu","family":"Khanra","sequence":"additional","affiliation":[{"name":"New Cross Hospital Royal Wolverhampton NHS Trust Wolverhampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Kup\u00f3","sequence":"additional","affiliation":[{"name":"University of Szeged Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Bunch","sequence":"additional","affiliation":[{"name":"Intermountain Heart Institute Intermountain Medical Center Murray UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue A.","family":"Theus","sequence":"additional","affiliation":[{"name":"Memphis VA Medical Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anindya","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Cardiology NRS Medical College Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit K.","family":"Shah","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Kom\u00f3csi","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adedayo","family":"Adeboye","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Jefferies","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.07.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12608"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13807"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.09.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux275"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv132"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy278"},{"key":"e_1_2_8_9_1","first-page":"1","article-title":"Uninterrupted anticoagulation during catheter ablation for atrial fibrillation: no difference in major bleeding and stroke between direct oral anticoagulants and vitamin K antagonists in an updated meta\u2010analysis of randomised controlled trials [published online February 14, 2020]","author":"Brockmeyer M","year":"2020","journal-title":"Acta Cardiol"},{"issue":"11","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0735-1097(20)31150-5","article-title":"Uninterrupted vs. interrupted novel oral anticoagulant (noac) dosing strategy before catheter ablation of atrial fibrillation: a metanalysis of randomized controlled trials for periprocedural complications","volume":"75","author":"Basu Ray I","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_8_11_1","unstructured":"RStudio Team.RSTudio: integrated development for R.2015.http:\/\/www.rstudio.com\/. 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