{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:28:52Z","timestamp":1782322132784,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is expected that ablation procedures will be increasingly offered to a more aged population affected with persistent AF (persAF); however, the clinical outcomes of ablation in this specific population are not well described. We aimed to analyze the efficacy and safety of CB\u2010A in this group of patients compared with a younger cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eighty\u2010three patients with (persAF) aged \u226575\u00a0years (group 1; mean age 78.2\u00a0\u00b1\u00a03.1\u00a0years) and 166 patients also affected with persAF aged &lt;75\u00a0years (group 2; mean age 64.3\u00a0\u00b1\u00a06.6\u00a0years) were included in the study. The primary outcome was freedom from recurrent sustained (&gt;30\u00a0seconds) atrial arrhythmias without anti\u2010arrhythmic medication after a blanking period of 3\u00a0months. At 2\u00a0years, clinical success was achieved in 108 out of 249 patients (43.4%). Median follow\u2010up was 24\u00a0months (IQR: 18.4\u201025.5\u00a0months). Older patients suffered from more recurrences than those in the younger cohort ((53\/83 patients, 63.9% vs 88\/166 patients, 53.0%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Thirty (12.0%) patients suffered a complication, but the incidence of complications was not different between both groups. The most frequent complication was transient phrenic nerve injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The global 2\u00a0years efficacy of CB\u2010A PVI in persAF is 43.4%. A lower success rate is achieved in the older patients (36.1%) compared to the younger age group (47.0%). However, the complication rate was not different between age groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12531","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T07:10:15Z","timestamp":1616742615000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of the second\u2010generation cryoballoon ablation for the treatment of persistent atrial fibrillation in elderly patients"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-7188","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Vermeersch","sequence":"first","affiliation":[{"name":"Electrophysiology Unit ZNA Heart Centre Middelheim Antwerpen 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