{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:11:38Z","timestamp":1773036698428,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An implantable cardioverter defibrillator (ICD) is the most reliable therapeutic device for preventing sudden cardiac death in patients with sustained ventricular tachycardia (VT). Regarding its effectiveness, targeted VT is defined based on the tachyarrhythmia cycle length. However, variations in RR interval variability of VTs may occur. Few studies have reported on VT characteristics and effects of ICD therapy according to the RR interval variability. We aimed to identify the clinical characteristics of VTs and ICD therapy effects according to the RR interval variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 821 VT episodes in 69 patients with ICDs or cardiac resynchronization therapy defibrillators. VTs were classified as irregular when the difference between two successive beats was &gt;20\u00a0ms in at least one of 10 RR intervals; otherwise, they were classified as regular. We evaluated successful termination using anti\u2010tachycardia pacing (ATP)\/shock therapy, spontaneous termination, and acceleration between regular and irregular VTs. The RR interval variability reproducibility rates were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regular VT was significantly more successfully terminated than irregular VT by ATP. No significant difference was found in shock therapy or VT acceleration between the regular and irregular VTs. Spontaneous termination occurred significantly more often in irregular than in regular VT cases. The reproducibility rates of RR interval variability in each episode and in all episodes were 89% and 73%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ATP therapy showed greater effectiveness for regular than for irregular VT. Spontaneous termination was more common in irregular than in regular VT. RR interval variability of VTs seems to be reproducible.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12551","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T07:31:56Z","timestamp":1621323116000},"page":"1052-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["RR interval variability in the evaluation of ventricular tachycardia and effects of implantable cardioverter defibrillator therapy"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-6367","authenticated-orcid":false,"given":"Keita","family":"Tsukahara","sequence":"first","affiliation":[{"name":"The Second Department of Internal Medicine University of Occupational and Environment Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-7791","authenticated-orcid":false,"given":"Yasushi","family":"Oginosawa","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine University of Occupational and Environment Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Fujino","sequence":"additional","affiliation":[{"name":"The Department of Environmental Epidemiology Institute of Industrial Ecological Sciences University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kumamoto Junkankika Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Japan Community Healthcare Organization Kyushu Hospital Kitakyusyu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Nozoe","sequence":"additional","affiliation":[{"name":"Division of Cardiology Saiseikai Fukuoka General Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3319-6316","authenticated-orcid":false,"given":"Hitoshi","family":"Minamiguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Osaka Police Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sasebo City General Hospital Sasebo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-1996","authenticated-orcid":false,"given":"Masahiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fukuoka University School of Medicine Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ideguchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Circulatory and Body Fluid Regulation Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Kizaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sasebo Chuo Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kageyuki","family":"Oba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yuai Medical Center Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-6249","authenticated-orcid":false,"given":"Satoshi","family":"Higa","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Laboratory Division of Cardiovascular Medicine Makiminato Central Hospital Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saga\u2010ken Medical Centre Koseikan Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishiro","family":"Yagyu","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine University of Occupational and Environment Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine University of Occupational and Environment Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-7468","authenticated-orcid":false,"given":"Yasunobu","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine University of Occupational and Environment Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaharu","family":"Ohe","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine University of Occupational and Environment Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of 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