{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:01:35Z","timestamp":1781877695350,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prescribing patterns for stroke prevention in atrial fibrillation (AF) patients evolved with approval of non\u2010Vitamin K antagonist oral anticoagulants (NOACs) over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess changes in anticoagulant prescription patterns in various geographical regions upon first approval of a NOAC and to analyze the evolution of oral anticoagulants (OACs) use over time in relation to CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc and HAS\u2010BLED risk profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Global Registry on Long\u2010Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation <jats:bold>(<\/jats:bold>GLORIA\u2010AF) Phases II and III reported data on antithrombotic therapy for patients with newly diagnosed AF and \u22651 stroke risk factor. We focused on sites enrolling patients in both phases and reported treatment patterns for the first 4\u00a0years after initial NOAC approval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From GLORIA\u2010AF Phases II and III, 27\u00a0432 patients were eligible for this analysis. When contrasting the first year with the fourth year of enrolment, the proportion of NOAC prescriptions increased in Asia from 29.2% to 60.8%, in Europe from 53.4% to 75.8%, in North America from 49.0% to 73.9% and in Latin America from 55.7% to 71.1%. The proportion of Vitamin K antagonists (VKAs) use decreased across all regions over time, in Asia from 26.0% to 9.8%, in Europe from 35.5% to 16.8%, in North America from 28.9% to 12.1%, and in Latin America from 32.4% to 17.8%. In the multivariable analysis, factors associated with NOAC prescription were as follows: enrolment year, type of site, region, stroke and bleeding risk scores, and type and categorization of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During 4\u00a0years after the approval of the first NOAC, NOAC use increased, while VKA use decreased, across all regions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12588","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T10:06:05Z","timestamp":1625911565000},"page":"990-1006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Changes in anticoagulant prescription patterns over time for patients with atrial fibrillation around the world"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-1975","authenticated-orcid":false,"given":"Monika","family":"Kozie\u0142","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart and Chest Hospital Liverpool UK"},{"name":"Department of Cardiology and Angiology Silesian Centre for Heart Diseases Zabrze Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Teutsch","sequence":"additional","affiliation":[{"name":"Department of Clinical Development and Medical Affairs Therapeutic Area Cardiometabolism Boehringer Ingelheim International GmbH Ingelheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bayer","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Sciences Department Boehringer Ingelheim Pharmaceuticals, Inc. 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Ridgefield CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh K.","family":"Gurusamy","sequence":"additional","affiliation":[{"name":"Global Epidemiology Boehringer Ingelheim International GmbH Ingelheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Halperin","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Rothman","sequence":"additional","affiliation":[{"name":"RTI Health Solutions Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Christoph","family":"Diener","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Sheng","family":"Ma","sequence":"additional","affiliation":[{"name":"University of Duisburg\u2010Essen Essen Germany"},{"name":"Cardiology Department Atrial Fibrillation Center Beijing Anzhen Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno V.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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