{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:22:00Z","timestamp":1774311720602,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial appendage (LAA) isolation (LAAI) has been described as an adjunctive ablation strategy for patients with recurrent atrial tachyarrhythmia (ATa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We compared the clinical impact of persistent durable LAAI between radiofrequency (RF)\u2010guided wide\u2010area LAAI and cryoballoon (CB)\u2010guided ostial LAAI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent RF\u2010 or CB\u2010guided LAAI were retrospectively analyzed. RF\u2010guided LAAI was performed by combining linear ablation. CB\u2010guided LAAI was performed by LAA ostial ablation. Following LAAI, the patients underwent an invasive remapping study. LAA closure was conducted if persistent durability was confirmed. The procedural data, LAAI durability, and ATa recurrence were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 260 patients (RF: <jats:italic>n<\/jats:italic>\u00a0=\u00a0201; CB: <jats:italic>n<\/jats:italic>\u00a0=\u00a059) undergoing LAAI were identified. The acute rate of procedural LAAI was higher in the CB group (CB:94.9% vs. RF:82.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) with a lower pericardial effusion incidence (CB:0% vs. RF:7.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). The 6\u2010week durable LAAI was similar between the two groups (RF:78.3% vs. CB:66.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.103). During follow\u2010up, one gastrointestinal bleeding and four stroke events including one subsequent intracranial bleeding leading to death occurred in the RF group, while one gastrointestinal bleeding occurred in the CB group.<\/jats:p><jats:p>The 1\u2010year ATa recurrence\u2010free rate was higher in patients with durable LAAI following RF\u2010guided LAAI (RF:76.3% vs. CB:56.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0017). Multivariate analysis revealed RF\u2010guided LAAI as a predictor of freedom from ATa recurrence (HR: 0.478, 95%CI: 0.336\u20130.823, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LAAI can be more readily and safely achieved by CB\u2010guided ostial ablation. In patients with confirmed LAAI, however, the freedom from ATa recurrence was higher after RF\u2010guided wide\u2010area isolation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12691","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T09:18:50Z","timestamp":1646731130000},"page":"316-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hot or cold? Feasibility, safety, and outcome after radiofrequency\u2010guided versus cryoballoon\u2010guided left atrial appendage isolation"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-362X","authenticated-orcid":false,"given":"Shota","family":"Tohoku","sequence":"first","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA); Abteilung f\u00fcr Kardiologie, Medizinische Klinik\u00a0III Agaplesion Markus Krankenhaus  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-9573","authenticated-orcid":false,"given":"Shaojie","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA); Abteilung f\u00fcr Kardiologie, Medizinische Klinik\u00a0III Agaplesion Markus Krankenhaus  Frankfurt am Main Germany"},{"name":"Die Sektion Medizin Universit\u00e4t zu L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0282-4658","authenticated-orcid":false,"given":"Stefano","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA); Abteilung f\u00fcr Kardiologie, Medizinische Klinik\u00a0III Agaplesion Markus Krankenhaus  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-6015","authenticated-orcid":false,"given":"Julian Kyoung\u2010Ryul","family":"Chun","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA); Abteilung f\u00fcr Kardiologie, Medizinische Klinik\u00a0III Agaplesion Markus Krankenhaus  Frankfurt am Main Germany"},{"name":"Die Sektion Medizin Universit\u00e4t zu L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-9906","authenticated-orcid":false,"given":"Boris","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA); Abteilung f\u00fcr Kardiologie, Medizinische Klinik\u00a0III Agaplesion Markus Krankenhaus  Frankfurt am Main Germany"},{"name":"Universit\u00e4tsklinikum Frankfurt Medizinische Klinik 3\u2010 Klinik f\u00fcr Kardiologie  Frankfurt 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