{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:54:16Z","timestamp":1780448056864,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The value of additional ablation beyond pulmonary vein isolation for atrial fibrillation (AF) ablation is unclear, especially for persistent AF. It is uncertain whether substrate modification with additional extensive ablation improves outcomes. We reviewed our experience to determine whether pulmonary vein isolation with additional extensive ablation (PVIEA) improves outcomes compared to pulmonary vein isolation alone (PVIA) for AF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive cases of patients with PVIA versus PVIEA were compared between September 9, 2013 and December 12, 2020. Procedural data collected include radiofrequency ablation delivery time (RADT) and arrhythmia inducibility. Clinical data collected include sinus rhythm maintenance post\u2010procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 235 patients were studied (67 PVIA and 168 PVIEA). RADT was shorter when comparing ablation with PVIA versus PVIEA (32 vs. 40\u2009min; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). More arrhythmias were inducible with PVIEA (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). There was no difference in sinus rhythm maintenance by Kaplan\u2013Meier survival analysis (log\u2010rank test <jats:italic>p<\/jats:italic>\u00a0=\u00a0.75), after 3 or 12\u00a0months between groups overall, and when stratified by AF type (paroxysmal and persistent), left atrial volume, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score, left ventricular ejection fraction, or catheter ablation setting (high\u2010power short\u2010duration, standard\u2010power standard\u2010duration, temperature\u2010controlled non\u2010contact\u2010force).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AF ablation with PVIA or PVIEA produces similar sinus rhythm maintenance overall and when stratified by catheter setting and AF type. PVIA reduced procedure times and less arrhythmias were inducible post\u2010ablation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12727","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T05:44:30Z","timestamp":1651556670000},"page":"589-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pulmonary vein isolation alone versus pulmonary vein isolation with additional extensive ablation for paroxysmal and persistent atrial fibrillation"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-1478","authenticated-orcid":false,"given":"Joey","family":"Junarta","sequence":"first","affiliation":[{"name":"Department of Medicine Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Dikdan","sequence":"additional","affiliation":[{"name":"Jefferson Heart 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