{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:23:54Z","timestamp":1747149834172,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The coexistence of clinical atrioventricular nodal reentrant tachycardia (AVNRT) and drug\u2010induced type 1 Brugada pattern (DI\u2010Type 1 BrP) has been previously reported. The present study was designed to determine the 12\u2010lead ECG characteristics at baseline and during AVNRT and to identify a subset of 12\u2010lead ECG variables of benefit associated with underlying Brugada syndrome (BrS)\/DI\u2010Type 1 BrP among patients with slow\/fast AVNRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 40 (11 numerical\/29 categorical) 12\u2010lead ECG parameters were analyzed and compared between patients with (<jats:italic>n<\/jats:italic>\u00a0=\u200969) and without (<jats:italic>n<\/jats:italic>\u00a0=\u2009104) BrS\/DI\u2010Type1\u2010BrP matched for age, female gender, body mass index, left ventricular ejection fraction and comorbid conditions. Five distinct types of ECG pattern (Type A\/B\/C\/D\/E) in V1\u2013V2 leads during AVNRT were defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of nine electrocardiographic variables, four at baseline, and five during AVNRT were identified. At baseline, patients with BrS\/DI\u2010Type 1 BrP had higher prevalence of interatrial block, leftward shift of frontal plane QRS axis, the absence of normal QRS pattern (the presence of rSr\u2019 pattern or type 2\/3 Brugada pattern) in V1\u2013V2 and QRS fragmentation in inferior leads compared to patients without BrS\/DI\u2010Type 1 BrP. During AVNRT, patients with BrS\/DI\u2010Type 1 BrP had higher prevalence of Type A ECG pattern (\u201ccoved\u2010type\u201d ST\u2010segment elevation) in V1\u2013V2, Type C ECG pattern (pseudo\u2010r\u2019 deflection in V<jats:sub>1<\/jats:sub> and \u201cRBBB\u2010like\u201d pattern in V<jats:sub>2<\/jats:sub>), pseudo\u2010r\u2019 deflection in V<jats:sub>1<\/jats:sub>, QRS fragmentation in inferior leads and \u201cisolated\u201d QRS fragmentation\/notching\/slurring in aVL compared to patients without BrS\/DI\u2010Type 1 BrP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identify several electrocardiographic variables that point to an underlying type 1 BrP among patients with slow\/fast AVNRT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12729","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T06:15:39Z","timestamp":1651904139000},"page":"633-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrocardiographic variables associated with underlying Brugada syndrome or drug\u2010induced Type 1 Brugada pattern in patients with slow\/fast atrioventricular nodal reentrant tachycardia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-9165","authenticated-orcid":false,"given":"Can","family":"Hasdemir","sequence":"first","affiliation":[{"name":"Department of Cardiology Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulten","family":"Duran","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet N.","family":"Orman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Kocabas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Baskent University Izmir Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Payzin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Aydin","sequence":"additional","affiliation":[{"name":"Tepecik Teaching and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Antzelevitch","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research  Wynnewood Pennsylvania USA"},{"name":"Lankenau Heart Institute  Wynnewood Pennsylvania USA"},{"name":"Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2016.07.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00680.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13414"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035411"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2018.09.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001557"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12241"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.033"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0972-6292(16)30544-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00653"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa193"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655746"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs291"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.01.030"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01239-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020484"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004765"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.862441"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.033"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000480"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90720-L"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.66.236"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.03.010"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/joa3.12729","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:53:37Z","timestamp":1692845617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/joa3.12729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/joa3.12729"],"URL":"https:\/\/doi.org\/10.1002\/joa3.12729","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"type":"print","value":"1880-4276"},{"type":"electronic","value":"1883-2148"}],"subject":[],"published":{"date-parts":[[2022,5,6]]},"assertion":[{"value":"2021-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}