{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:23:54Z","timestamp":1747149834441,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the Mid\u2010Q Response study is to test the hypothesis that adaptive preferential left ventricular\u2010only pacing with the AdaptivCRT algorithm has superior clinical outcomes compared to conventional cardiac resynchronization therapy (CRT) in heart failure (HF) patients with moderately wide QRS duration (\u2265120\u2009ms and &lt;150\u2009ms), left bundle branch block (LBBB), and normal atrioventricular (AV) conduction (PR interval \u2264200\u2009ms).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, multi\u2010center, randomized, controlled, clinical study is being conducted at approximately 60 centers in Asia. Following enrollment and baseline assessment, eligible patients are implanted with a CRT system equipped with the AdaptivCRT algorithm and are randomly assigned in a 1:1 ratio to have AdaptivCRT ON (Adaptive Bi\u2010V and LV pacing) or AdaptivCRT OFF (Nonadaptive CRT). A minimum of 220 randomized patients are required for analysis of the primary endpoint, clinical composite score (CCS) at 6\u2009months post\u2010implant. The secondary and ancillary endpoints are all\u2010cause and cardiovascular death, hospitalizations for worsening HF, New York Heart Association (NYHA) class, Kansas City Cardiomyopathy Questionnaire (KCCQ), atrial fibrillation (AF), and cardiovascular adverse events at 6 or 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Mid\u2010Q Response study is expected to provide additional evidence on the incremental benefit of the AdaptivCRT algorithm among Asian HF patients with normal AV conduction, moderately wide QRS, and LBBB undergoing CRT implant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12731","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T10:49:32Z","timestamp":1653043772000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design of <scp>Mid\u2010Q<\/scp> Response: A prospective, randomized trial of adaptive cardiac resynchronization therapy in Asian patients"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-9285","authenticated-orcid":false,"given":"Kengo","family":"Kusano","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine Samsung Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofian","family":"Johar","sequence":"additional","affiliation":[{"name":"Gleneagles Jerudong Park Medical Centre and Institute of Health Sciences Universiti Brunei Darussalam  Bandar Seri Begawan Brunei Darussalam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toon Wei","family":"Lim","sequence":"additional","affiliation":[{"name":"National University Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Gerritse","sequence":"additional","affiliation":[{"name":"Medtronic Bakken Research Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-7647","authenticated-orcid":false,"given":"Kazuhiro","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Medtronic Japan  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Aonuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine University of Tsukuba  Tsukuba 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