{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:11:38Z","timestamp":1776910298968,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sarcoidosis is a systemic inflammatory disorder associated with ventricular arrhythmias (VAs) and sudden death in the context of cardiac involvement. Guidelines advocate implantable cardioverter\u2010defibrillator (ICD) implantation in specific subcohorts, but there is a paucity of data on outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A systematic review was performed to assess outcomes in patients with definite or probable cardiac sarcoidosis (CS) treated with ICD. Observational studies were identified from multiple databases from inception to 21st May 2021. Outcomes of interest included appropriate and inappropriate ICD therapies in addition to all\u2010cause mortality. Study quality was assessed individually using the Newcastle Ottawa Scale (NOS).<\/jats:p><jats:p>Eight studies were identified comprising 530 patients, with follow\u2010up period of 24\u201366\u00a0months (weighted average 40\u00a0months). Mean age was 53.9\u2009years with ejection fraction of 41.3%. Overall incidence of appropriate therapy was 38.1% during follow\u2010up. Left ventricular systolic dysfunction (LVSD) with ejection fraction &lt;40% was a predictor of appropriate therapy in the majority of studies, as were sustained VAs during electrophysiological testing (EP) in one study. There was no interaction with device indication (i.e. primary or secondary). Where documented, inappropriate therapy was primarily driven by atrial arrhythmias. All\u2010cause mortality was 6.0% over a median follow\u2010up period of 42\u00a0months. Only three studies achieved good quality in the comparability domain of NOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Appropriate ICD therapy in patients with CS is commonly associated with LVSD, which can act as a surrogate for scar burden. The utility of EP testing in this setting remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12753","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:54:17Z","timestamp":1658566457000},"page":"710-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes after transvenous defibrillator implantation in cardiac sarcoidosis: A systematic review"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-7260","authenticated-orcid":false,"given":"Ahmed","family":"Taha","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leeds General Infirmary  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Assaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology Blackpool Victoria Hospital  Blackpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asgher","family":"Champsi","sequence":"additional","affiliation":[{"name":"Department of Cardiology New Cross Hospital  Wolverhampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Nadarajah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leeds General Infirmary  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peysh A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60680-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12888-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-249OC"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2008.03.007"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.406"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-970335"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0263"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.851352"},{"issue":"7","key":"e_1_2_12_10_1","first-page":"377","article-title":"Pathological studies on sarcoidosis autopsy. 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