{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:37:52Z","timestamp":1757309872372,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is uncertain whether cardiac resynchronization therapy with a defibrillator (CRT\u2010D) provides better survival benefits than a CRT\u2010pacemaker (CRT\u2010P) in heart failure patients with a reduced ejection fraction (\u226635%, HFrEF) treated with contemporary HF therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the ventricular arrhythmia (VAs; sustained ventricular tachycardia\/fibrillation) events in HFrEF patients who underwent CRT without a prior history of VAs or aborted sudden cardiac death before the CRT implantation. Between January\/2010 and December\/2020, a CRT device was implanted in 79 HFrEF patients (mean age: 69\u2009\u00b1\u200912\u2009years, male: 57, ischemic cardiomyopathy: 16). CRT\u2010D and CRT\u2010P devices were implanted in 50 and 29 patients, respectively, at each physician's discretion. CRT\u2010Ds were indicated in younger patients than were CRT\u2010Ps (66\u2009\u00b1\u200912 vs. 73\u2009\u00b1\u200912\u2009years, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), but the gender distribution did not differ (female, 24% [12 of 50] vs. 35% [10 of 29], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.44). The VA events during a median follow\u2010up of 3.5\u2010years (interquartile range [IQR]:1.6\u20135.5) and their predictors were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VA events occurred in 9 patients with CRT\u2010Ds (18%) and one with a CRT\u2010P (3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.08). The VA event rate was significantly lower in patients without a prior non\u2010sustained ventricular tachycardia (NSVT: \u22653 beats; rate, \u2265120\u2009bpm; lasting &lt;30\u2009s, HR 0.05; 95% CI 0.01\u20130.30; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and females (HR 0.11; 95% CI 0.01\u20130.93; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Of note, no female patients without a prior history of NSVT experienced VA events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HFrEF CRT candidates without a prior history of NSVT and females may obtain less benefit from a primary preventive defibrillator indication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12795","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:33:41Z","timestamp":1667208821000},"page":"1056-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ventricular arrhythmia events in heart failure patients with cardiac resynchronization therapy with or without a defibrillator for primary prevention"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-3008","authenticated-orcid":false,"given":"Toshihiro","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-4854","authenticated-orcid":false,"given":"Kunihiko","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-802X","authenticated-orcid":false,"given":"Mitsuru","family":"Takami","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takahara","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-9932","authenticated-orcid":false,"given":"Kazutaka","family":"Nakasone","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-0914","authenticated-orcid":false,"given":"Yuya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe 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Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Yonehara","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010ichi","family":"Hirata","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University 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