{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:11:07Z","timestamp":1782821467320,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interatrial conduction time (IACT) prolongs in fibrotic left atrium. We tested the hypothesis that IACT is related to left atrial low voltage area (LVA) and predicts the recurrence after single atrial fibrillation (AF) ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred sixty\u2010four consecutive AF patients (79 non\u2010paroxysmal) who underwent initial ablation in our institute were analyzed. IACT and LVA were defined as interval from the onset of P\u2010wave to the basal left atrial appendage (P\u2010LAA) activation, and area with bipolar electrogram &lt; 0.5\u00a0mV covering over 5% of the total left atrial surface area during sinus rhythm, respectively. Pulmonary vein antrum isolation, non\u2010PV foci ablation, and atrial tachycardia (AT) ablation were performed without substrate modification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVA was frequently identified in patients with prolonged P\u2010LAA\u2009\u2265\u200984\u2009ms (<jats:italic>n<\/jats:italic> \u00a0=\u200928) compared with patients with P\u2010LAA\u2009&lt;\u200984\u2009ms (<jats:italic>n<\/jats:italic> \u00a0=\u2009136). Patients with P\u2010LAA\u2009\u2265\u200984\u2009ms were older (71\u2009\u00b1\u200910 vs. 65\u2009\u00b1\u200910\u2009years, <jats:italic>p<\/jats:italic> \u00a0=\u2009.0061), and had more frequent non\u2010paroxysmal AF (75% vs. 43%, <jats:italic>p<\/jats:italic> \u00a0=\u2009.0018), larger left atrial diameter (43.5\u2009\u00b1\u20094.5 vs. 39.3\u2009\u00b1\u20095.7\u2009mm, <jats:italic>p<\/jats:italic> \u00a0=\u2009.0003), and higher E\/e\u2019 ratio (14.4\u2009\u00b1\u20096.5 vs. 10.5\u2009\u00b1\u20093.7, <jats:italic>p<\/jats:italic> \u00a0&lt;\u2009.0001) compared with P\u2010LAA\u2009&lt;\u200984\u2009ms patients. After a mean follow\u2010up period of 665\u2009\u00b1\u2009153\u2009days, Kaplan\u2013Meier curve analysis showed that AF\/AT recurrences was more frequently observed in patients with prolonged P\u2010LAA (Log\u2010rank <jats:italic>p<\/jats:italic> \u00a0=\u2009.0001). Additionally, univariate analysis revealed that P\u2010LAA prolongation (OR\u00a0=\u00a01.055 per 1\u00a0ms, 95% CI: 1.028\u20131.087, <jats:italic>p<\/jats:italic> \u00a0&lt;\u2009.0001) and the existence of LVA (OR\u00a0=\u00a05.000, 95% CI: 1.653\u201314.485 <jats:italic>p<\/jats:italic> \u00a0=\u2009.0053) were predictors of AF\/AT recurrences after single AF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggested that prolonged IACT as measured by P\u2010LAA was associated with LVA and predicts AT\/AF recurrence after single AF ablation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12820","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T07:00:52Z","timestamp":1674543652000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interatrial conduction time is associated with left atrial low voltage area and predicts the recurrence after single atrial fibrillation ablation"],"prefix":"10.1002","volume":"39","author":[{"given":"Kei","family":"Hirota","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination Oita University  Yufu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-6433","authenticated-orcid":false,"given":"Akira","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination Oita University  Yufu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-1892","authenticated-orcid":false,"given":"Masaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department 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