{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:24:10Z","timestamp":1747149850419,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency ablation (RFA) is the standard of care in the management of supraventricular tachycardia (SVT). Its cost\u2010effectiveness in an emerging Asian country has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A cost\u2010utility analysis of RFA versus optimal medical therapy (OMT) among Filipinos with SVT was conducted using the public healthcare provider's perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A simulation cohort using a lifetime Markov model was constructed using patient interviews, a review of literature, and expert consensus. Three basic health states were defined: stable, SVT recurrence, and death. The incremental cost per quality\u2010adjusted life year (ICER) was determined for both arms. Utilities for the entry states were derived from patient interviews using the EQ5D\u20105L tool; utilities for other health states were taken from publications. Costs were assessed from the healthcare payer perspective. A sensitivity analysis was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Base case analysis showed that RFA versus OMT is both highly cost\u2010effective at 5\u2009years and over a lifetime. RFA at 5\u2009years costs about PhP276,913.58 (USD5,446) versus OMT of PhP151,550.95 (USD2,981) per patient. Discounted lifetime costs were PhP280,770.32 (USD5,522) for RFA, versus PhP259,549.74 (USD5,105) for OMT. There was improved quality of life with RFA (8.1 vs. 5.7 QALYs per patient). The 5\u2010year and lifetime incremental cost\u2010effectiveness ratios were PhP148,741.40 (USD2,926) and Php15,000 (USD295), respectively. Sensitivity analysis showed 56.7% of simulations for RFA fell below a GDP\u2010benchmarked willingness\u2010to\u2010pay (WTP) threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the initial higher cost, RFA versus OMT for SVT is highly cost\u2010effective from the Philippine public health payer's perspective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12833","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T16:19:21Z","timestamp":1676996361000},"page":"175-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost\u2010utility analysis of radiofrequency ablation versus optimal medical therapy in managing supraventricular tachycardia among Filipinos"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-9177","authenticated-orcid":false,"given":"Giselle G.","family":"Gervacio","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of the Philippines\u2010Philippine General Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miharu J. M.","family":"Kimwell","sequence":"additional","affiliation":[{"name":"University of the Philippines School of Economics  Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3944-3469","authenticated-orcid":false,"given":"Erdie C.","family":"Fadreguilan","sequence":"additional","affiliation":[{"name":"Philippine Heart Center  Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denese C.","family":"De\u00a0Guzman","sequence":"additional","affiliation":[{"name":"Alliance for Improving Health Outcomes  Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Philippine Heart Center  Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara S.","family":"Tolentino","sequence":"additional","affiliation":[{"name":"St. Lukes Medical Center Bonifacio Global City  Taguig Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys R. S.","family":"David","sequence":"additional","affiliation":[{"name":"Philippine Heart Center  Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15502"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000311"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz467"},{"issue":"9","key":"e_1_2_11_5_1","first-page":"1689","article-title":"Asia PHRS. APHRS white book 2019","volume":"53","author":"Zhang S","year":"2006","journal-title":"APHRS White B 2019"},{"key":"e_1_2_11_6_1","first-page":"14","article-title":"Epidemiologic burden of hospitalization among adult Filipinos with supraventricular tachycardia requiring radiofrequency ablation","author":"Bermudez\u2010Delos Santos A","year":"2021","journal-title":"Phil J Cardiol"},{"key":"e_1_2_11_7_1","unstructured":"Philippine Health Insurance Corporation.List of Procedure Case Rates.2015:1\u201398.https:\/\/www.philhealth.gov.ph\/circulars\/2015\/annexes\/circ08_2014\/Annex2_ListofProcedureCaseRatesRevision1.pdf"},{"key":"e_1_2_11_8_1","unstructured":"Senate of the Philippines.\u201cRA 11223: an act instituting UNIVERSAL health care for all FILIPINOS prescribing reforms IN the health care system and appropriating funds therefor.\u201d Senate of the Philippines Legislative Archives and Records.2019."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw064"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010133\u201011\u2010200012050\u201000010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.2.262"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(00)01128\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e3283400ba2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109149(97)89123\u20100"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108167.1995.tb00371.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735\u20101097(91)90508\u20107"},{"key":"e_1_2_11_17_1","unstructured":"WHO.Life tables Philippines. Glob Heal Obs data Repos. Published Online2019.https:\/\/apps.who.int\/gho\/data\/view.main.LT62150?lang=en"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2012.07.003"},{"key":"e_1_2_11_19_1","unstructured":"The EuroQol group. EQ\u20105D\u20105L User Guide Version 2.1.EuroQol Res Found.2015.http:\/\/www.euroqol.org\/fileadmin\/user_upload\/Documenten\/PDF\/Folders_Flyers\/EQ\u20105D\u20105L_UserGuide_2015.pdf"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20108\u201013"},{"key":"e_1_2_11_21_1","unstructured":"AraR BrazierJ SculpherM MancaA BjokeL PrestonL et al.A Framework for Conducting Economic Evaluations When Using Patient Decision Aids in Health Care Decision Making.2015."},{"key":"e_1_2_11_22_1","unstructured":"DOH.The Philippine Drug Price Reference Index. Published online 2020.https:\/\/dpri.doh.gov.ph\/download\/2020\u2010DPRI\u2010Final\u2010Version\u201001\u201022.pdf"},{"key":"e_1_2_11_23_1","unstructured":"DOH.Standard Information Education and Communications (IEC) Materials for the Implementation of Maximum Drug Retail Price through Executive Order No. 155 s. 2021. Pharmaceutical Division Department of Health 2021.https:\/\/pharma.doh.gov.ph\/maximum\u2010drug\u2010retail\u2010price\/"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109149(02)02285\u20103"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17072334"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vhri.2015.06.002"},{"key":"e_1_2_11_27_1","unstructured":"PhilHealth.List of Medical Case Rates. Published online 2017.https:\/\/www.philhealth.gov.ph\/circulars\/2017\/annexes\/0019\/AnnexA\u2010MedicalCaseRates.pdf"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.018"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vhri.2015.06.002"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12962\u2010021\u201000260\u20100"},{"key":"e_1_2_11_31_1","first-page":"30","article-title":"The economic burden of hospitalization for cardiac arrhythmias requiring implantable cardioverter\u2010 defibrillator and radiofrequency ablation among adult Filipinos\u2014its clinical and equity implications and budget impact analysis of proposed revised PhilHealth case rates for cardioverter\u2010defibrillator implantation and radiofrequency ablation. Phil","author":"Tumanan\u2010Mendoza B","year":"2021","journal-title":"J Cardiol"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.09.014"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/joa3.12833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.12833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:28:48Z","timestamp":1692667728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/joa3.12833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/joa3.12833"],"URL":"https:\/\/doi.org\/10.1002\/joa3.12833","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"type":"print","value":"1880-4276"},{"type":"electronic","value":"1883-2148"}],"subject":[],"published":{"date-parts":[[2023,2,21]]},"assertion":[{"value":"2022-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}