{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:02:47Z","timestamp":1778086967087,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Determining the pathogenesis of sudden cardiac arrest (SCA) in children is crucial for its management and prognosis. Our aim is to analyze the role of broad genetic testing in the prevention, diagnosis, and prognosis of SCA in Children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ECG, 12\u2010lead holter, exercise testing, cardiac imaging, familial study, and genetic testing were used to study 29 families, in whom a child experienced SCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a thorough clinical and genetic evaluation a positive diagnosis was reached in 24\/29 (83%) families. Inherited channelopathies (long QT syndrome and catecholaminergic polymorphic ventricular tachycardia) were the most prevalent 20\/29 (69%) diagnosis, followed by cardiomyopathy 3\/29 (10%). Broad genetic testing was positive in 17\/24 (71%) cases. Using the Mann\u2013Whitney test, we found that genetic testing (effect size\u2009=\u20090.625, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), ECG (effect size\u2009=\u20090.61, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), and exercise test (effect size\u2009=\u20090.63, <jats:italic>p<\/jats:italic>\u2009=\u20090.047) had the highest yield in reaching the final diagnosis. Genetic testing was the only positive test available for five (17%) families. Among 155 family members evaluated through cascade screening, 73 (47%) had a positive clinical evaluation and 64 (41%) carried a pathologic mutation. During 6\u2009\u00b1\u20094.8\u2009years of follow\u2010up, 58% of the survived children experienced an arrhythmic event. Of nine family members who had an ICD implant for primary prevention, four experienced appropriate ICD shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The major causes of SCA among children are genetic etiology, and genetic testing has a high yield. Family screening has an additional role in both the diagnosis and preventing of SCA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12881","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T08:54:32Z","timestamp":1686560072000},"page":"607-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of genetic testing in the prevention, diagnosis, and prognosis of sudden cardiac arrest in children"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5004-275X","authenticated-orcid":false,"given":"Miry","family":"Blich","sequence":"first","affiliation":[{"name":"Inherited Arrhythmia Clinic Rambam Health Care Campus  Haifa Israel"},{"name":"Division of Pacing and Electrophysiology Rambam Health Care Campus  Haifa 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