{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:49:11Z","timestamp":1784688551694,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Panoramic studies in patients with cardiac resynchronization therapy with a defibrillator (CRT\u2010D) focusing on the etiology and indication are scarce. Besides, a controversy exists regarding requirement of a defibrillator in non\u2010ischemic patients for primary prevention with CRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Annual trends of de novo CRT\u2010D implantations from 2011 to 2020 and outcomes of those between January 2011 and August 2015 were analyzed from the Japan cardiac device treatment registry (JCDTR) and New JCDTR database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2011 to 2020, 8062 CRT\u2010D recipients were registered, whose dominant indication was primary prevention of sudden cardiac death with a steady rate of about 70%. There was no significant temporal change of the proportion of non\u2010ischemic patients being about 70% and 65% for primary and secondary prevention, respectively. Non\u2010ischemic patients for primary prevention were associated with increased odds of appropriate ICD therapy [adjusted hazard ratio (aHR): 1.66; 95% confidence interval (CI): 1.01\u20132.75; <jats:italic>p<\/jats:italic>\u2009=\u2009.047] and reduced odds of any death (aHR: 0.66; 95% CI: 0.44\u20130.99; <jats:italic>p<\/jats:italic>\u2009=\u2009.046) as compared to ischemic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Proportion of non\u2010ischemic etiology was much higher than that of ischemic one in the CRT\u2010D cohort. Based on the higher odds of appropriate ICD therapy, non\u2010ischemic patients for primary prevention appear to be prudently selected in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12916","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:33:06Z","timestamp":1692873186000},"page":"757-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac resynchronization therapy with a defibrillator in non\u2010ischemic and ischemic patients for primary and secondary prevention of sudden cardiac death: Analysis of the Japan cardiac device treatment registry database"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-2148","authenticated-orcid":false,"given":"Hisashi","family":"Yokoshiki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo City General Hospital  Sapporo 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Medicine Jichi Medical University School of Medicine  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yoshiga","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine and Clinical Science Yamaguchi University Graduate School of Medicine  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Heart Rhythm Management University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School  Bunkyo City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Members of the Implantable Cardioverter\u2010Defibrillator (ICD) Committee of the Japanese Heart Rhythm 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