{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:49:05Z","timestamp":1784033345575,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010induced life\u2010threatening ventricular arrhythmias including torsade de pointes (TdP), ventricular tachycardia (VT), and ventricular fibrillation (VF) are serious cardiac side effects. Psychotherapeutic drugs are known to be risk factors for arrhythmias. The aim of this study was to evaluate psychotherapeutic drugs associated with life\u2010threatening ventricular arrhythmias using the Japanese Adverse Drug Event Report (JADER) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the JADER database (April 2004 to September 2022), cases of TdP, VT, VF, and QT prolongation in patients taking psychotherapeutic drugs as \u2018suspected drugs\u2019 were extracted. The adjusted reported odds ratio (aROR) was calculated to identify potential drugs involved in combined TdP\/VF\/VT or combined QT prolongation\/TdP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 4,530,772 cases reported, life\u2010threatening arrhythmia\u2010related adverse events were reported in 1760 cases (QT prolongation 1261, TdP 192, VF 108, VT 199) among 909 patients; 58.9% of patients were female, and the highest incidence was among patients aged 80\u201389\u2009years (18.6%), followed by patients aged 70\u201379\u2009years (15.4%). The highest aROR for TdP\/VF\/VT was found for trazodone (17.1), followed by sulpiride (10.8), haloperidol (9.8), donepezil (9.1), and fluvoxamine (7.9). The highest aROR for QT prolongation\/TdP was found for guanfacine (87.8), followed by sultopride (60.1), escitalopram (21.0), trazodone (12.8), and donepezil (9.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that typical antipsychotics, antidepressants, and antidementia drugs were associated with life\u2010threatening arrhythmia\u2010related adverse events in a Japanese clinical setting. These events were more frequent in women and elderly individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12936","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:05:41Z","timestamp":1696349141000},"page":"928-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Psychotherapeutic drug\u2010induced life\u2010threatening arrhythmias: A retrospective analysis using the Japanese adverse drug event\u00a0report database"],"prefix":"10.1002","volume":"39","author":[{"given":"Saki","family":"Yokohara","sequence":"first","affiliation":[{"name":"The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-7196","authenticated-orcid":false,"given":"Tsuyoshi","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.11.1363"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371506000501"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.2.181"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806994"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.139"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001568"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"S24","article-title":"Evaluation of the profile of patients with QTc prolongation in spontaneous adverse event reporting over the past three decades\u20141969\u20131998","volume":"9","author":"Fung M","year":"2000","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-022-00328-0"},{"key":"e_1_2_11_10_1","unstructured":"https:\/\/www.pmda.go.jp\/safety\/info\u2010services\/drugs\/adr\u2010info\/suspected\u2010adr\/0004.html. 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