{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:27:43Z","timestamp":1784698063263,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Temporal change in outcomes of heart failure patients receiving cardiac resynchronization therapy with a defibrillator (CRT\u2010D) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assess outcomes and underlying heart diseases of patients receiving CRT\u2010D with analyzing database of the Japan cardiac device treatment registry (JCDTR) at the implantation year 2011\u20132015 and New JCDTR at the implantation year 2018\u20132021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Proportion of nonischemic heart diseases was about 70% in both the groups (JCDTR: 69%; New JCDTR: 72%). Cardiac sarcoidosis increased with the rate of 5% in the JCDTR to 9% in the New JCDTR group. During an average follow\u2010up of 21\u2009months, death from any cause occurred in 167 of 906 patients in the JCDTR group (18%) and 79 of 611 patients in the New JCDTR group (13%) (adjusted hazard ratio [aHR] in the New JCDTR group, 0.72; 95% confidence interval [CI]: 0.55\u20130.94; <jats:italic>p<\/jats:italic>\u2009=\u2009.017). The superiority was mainly driven by reduction in the risk of noncardiac death. With regard to appropriate and inappropriate implantable cardioverter\u2013defibrillator (ICD) therapy, there was a significant reduction in the New JCDTR group versus the JCDTR group (aHR in the New JCDTR group, 0.76; 95% CI: 0.59\u20130.98; <jats:italic>p<\/jats:italic>\u2009=\u2009.032 for appropriate ICD therapy; aHR in the New JCDTR group, 0.24; 95% CI: 0.12\u20130.50; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001 for inappropriate ICD therapy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All\u2010cause mortality was reduced in CRT\u2010D patients implanted during 2018\u20132021 compared to those during 2011\u20132015, with a significant reduction in noncardiac death.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12952","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:11:11Z","timestamp":1699945871000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-2148","authenticated-orcid":false,"given":"Hisashi","family":"Yokoshiki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo City General Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"UBE Kohsan Central Hospital  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-4819","authenticated-orcid":false,"given":"Takeshi","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hoshi General Hospital  Koriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-4303","authenticated-orcid":false,"given":"Tomoyuki","family":"Kabutoya","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Jichi Medical University School of Medicine  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yoshiga","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine and Clinical Science Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-6929","authenticated-orcid":false,"given":"Yusuke","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Heart Rhythm Management University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Members of the Implantable Cardioverter\u2010Defibrillator (ICD) Committee of the Japanese Heart Rhythm 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