{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:31:38Z","timestamp":1783650698574,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Programmed ventricular stimulation (PVS) during electrophysiological study (EPS), is a globally accepted tool for risk stratification of sudden cardiac death (SCD) in some specific clinical situations. The aim of this study was to evaluate the prognosis of ventricular arrhythmia induction in a cohort of patients with syncope of undetermined origin (SUO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a historical cohort study in a population of patients with SUO referred for EPS between the years 2008\u20132021. In this interval, 575 patients underwent the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with induced ventricular arrhythmias had a higher occurrence of structural heart disease (36.7% vs. 76.5%), ischemic heart disease (28.2 vs. 57.1%), heart failure (15.5% vs. 34.4%), and lower left ventricular ejection fraction (59.16% vs. 47.51%), when compared to the outcome with a negative study. PVS triggered ventricular arrhythmias in 98 patients, 62 monomorphic and 36 polymorphic. During a median follow\u2010up of 37.6\u2009months, 100 deaths occurred. Only the induction of sustained ventricular arrhythmias showed a significant association with the primary outcome (all\u2010cause mortality) with a <jats:italic>p<\/jats:italic> value &lt;.001. After the performance of EPS, 142 patients underwent cardioverter\u2010defibrillator (ICD) implantation. At study follow\u2010up, 30 patients had therapies by the device. Only the induction of sustained monomorphic ventricular arrhythmia showed statistically significant association with appropriate therapies by the device (<jats:italic>p<\/jats:italic>\u2009=\u2009.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with SUO, the induction of sustained monomorphic ventricular arrhythmia after programmed ventricular pacing is related to a worse prognosis, with a higher incidence of mortality and appropriate therapies by the ICD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.12953","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:18:08Z","timestamp":1700065088000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognosis of programmed ventricular stimulation in adult patients with syncope of unexplained origin: A historical cohort"],"prefix":"10.1002","volume":"40","author":[{"given":"Bruno Schaaf","family":"Finkler","sequence":"first","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sant'Anna","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pinos","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Barros","family":"Zanotta","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Camargo","family":"Moreira","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Della Barba","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Dutra","family":"Batista","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Guedes","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Adelmann","family":"de Lima","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8232-3310","authenticated-orcid":false,"given":"Marco Aur\u00e9lio Lumertz","family":"Saffi","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Glotz","family":"de Lima","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Kruse","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Luiz Luz","family":"Leiria","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande, do Sul, Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"GrossmanSA BadireddyM.Syncope. 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