{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T17:38:54Z","timestamp":1774719534537,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implantable cardioverter\u2010defibrillator (ICD) offers an opportunity to study inducibility of ventricular tachycardia (VT) or ventricular fibrillation (VF) by performing noninvasive programmed ventricular stimulation (NIPS). Whether NIPS can predict future arrhythmic events or mortality in patients with primary prevention ICD, has not yet been examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the NIPS\u2010ICD study (ClinicalTrials ID: NCT02373306) 41 consecutive patients (34 males, age 64\u2009\u00b1\u200911\u2009years, 76% ischemic cardiomyopathy [ICM]) had ICD for primary prevention indication. Patients underwent NIPS using a standardized protocol of up to three premature extrastimuli at 600, 500 and 400\u2009ms drive cycle lengths. NIPS was classified as positive if sustained VT or VF was induced. The study endpoint was occurrence of sustained VT\/VF during the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline NIPS, VT\/VF was induced in 8 (20%) ICM patients. During the 5\u2010year follow\u2010up, the VT\/VF occurred in 7 (17%) patients, all with ICM. The difference between NIPS\u2010inducible versus NIPS\u2010noninducible patients regarding VT\/VF occurrence did not meet statistical significance (38% vs. 12%, log rank test <jats:italic>p<\/jats:italic>\u2009=\u2009.11). After a 5\u2010year follow\u2010up, the mortality rate was significantly higher in patients who had VT\/VF induced at NIPS versus no VT\/VF at NIPS (38% vs. 12%, <jats:italic>p<\/jats:italic>\u2009=\u2009.043). The occurrence of a composite endpoint consisting of VT\/VF recurrence or death in patients with ICM was also most frequent in the NIPS\u2010inducible group (75% vs. 35%, <jats:italic>p<\/jats:italic>\u2009=\u2009.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inducibility of VT\/VF during NIPS in ICM patients with primary prevention ICD is associated with higher mortality and higher incidence of composite endpoint consisting of death or VT\/VF during a long\u2010term observation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.13017","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T09:39:18Z","timestamp":1710495558000},"page":"578-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of noninvasive programmed stimulation in primary prevention implantable cardioverter\u2010defibrillator recipients"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0219-7612","authenticated-orcid":false,"given":"Piotr","family":"Futyma","sequence":"first","affiliation":[{"name":"St. Joseph's Heart Rhythm Center  Rzesz\u00f3w Poland"},{"name":"Medical College University of Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Zar\u0119bski","sequence":"additional","affiliation":[{"name":"St. Joseph's Heart Rhythm Center  Rzesz\u00f3w Poland"},{"name":"Medical College University of Rzesz\u00f3w  Rzesz\u00f3w 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ku\u0142akowski","sequence":"additional","affiliation":[{"name":"St. Joseph's Heart Rhythm Center  Rzesz\u00f3w Poland"},{"name":"Department of Cardiology, Centre of Postgraduate Medical Education Grochowski Hospital  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.66.2.2071244"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.11.027"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1994.tb01510.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.02.039"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02362.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13523"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1170-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90320-Z"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1994.tb02374.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.026"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005602"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.03.007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14516"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.3.518"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002295"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91173-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613773"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608029"}],"container-title":["Journal 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