{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:37:48Z","timestamp":1787593068593,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationships between frailty and clinical outcomes in elderly Japanese patients with non\u2010valvular atrial fibrillation (NVAF) after catheter ablation (CA) have not been established. We evaluated the frailty rate of patients undergoing CA for NVAF, examined whether CA for NVAF improves frailty, and analyzed the CA outcomes of patients with and without frailty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Elderly Japanese patients (\u226565\u2009years; mean age: 72.8\u2009years) who participated in the real\u2010world ablation therapy with anti\u2010coagulants in management of atrial fibrillation registry and who responded to the frailty screening index survey were included (<jats:italic>n<\/jats:italic>\u2009=\u2009213). Frailty and AF recurrence were assessed preoperatively and at 3 and 6\u2009months after CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients (12.8%) were frail, 109 (53.7%) were pre\u2010frail, and 68 (33.5%) were robust. Cardiovascular (frailty: 0.5%\/person\u2010year; pre\u2010frailty: 0.1%\/person\u2010year; robust: 0.1%\/person\u2010year) and cardiac (frailty: 0.5%\/person\u2010year; pre\u2010frailty: 0.1%\/person\u2010year; robust: 0.1%\/person\u2010year) events, as well as major bleeding (frailty: 0.3%\/person\u2010year; pre\u2010frailty: 0.1%\/person\u2010year; robust: 0.1%\/person\u2010year), were numerically more frequent in the frailty group. No deaths from cardiovascular or stroke\/systemic thromboembolic events occurred. A large proportion of patients did not experience 3\u2010month (frailty: 96.2%; pre\u2010frailty: 96.3%; robust: 88.2%) or 6\u2010month (frailty: 88.5%; pre\u2010frailty: 91.7%; robust: 86.8%) AF recurrence after CA. Weight loss, walking speed, and fatigue improved in the frailty and pre\u2010frailty groups after CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Japanese patients aged \u226565\u2009years with frailty or pre\u2010frailty had improved frailty screening index components, such as weight loss, walking speed and fatigue, after CA. Therefore, elderly patients with frailty or pre\u2010frailty may benefit from CA for NVAF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.13038","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T05:03:55Z","timestamp":1712725435000},"page":"463-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of frailty in patients with non\u2010valvular atrial fibrillation undergoing catheter ablation"],"prefix":"10.1002","volume":"40","author":[{"given":"Kyoko","family":"Soejima","sequence":"first","affiliation":[{"name":"Department of Cardiology Kyorin University School of Medicine  Mitaka Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Nogami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-5565","authenticated-orcid":false,"given":"Koichiro","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Fukuoka Sanno Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikuya","family":"Uno","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Tokyo Heart Rhythm Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Center Kindai University School of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-090X","authenticated-orcid":false,"given":"Itsuro","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiharu","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima Prefectural Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-8708","authenticated-orcid":false,"given":"Ritsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Arrhythmia Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kimura","sequence":"additional","affiliation":[{"name":"Primary Medical Science Department Daiichi Sankyo Co., Ltd.  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