{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:00:36Z","timestamp":1768698036230,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have shown inconsistent results in clinical effectiveness between cryoballoon ablation (CBA) and radiofrequency ablation (RFA), and cost assessment between the procedures is important. The aim of this study was to evaluate the clinical effectiveness and cost\u2010effectiveness between the procedures in patients with paroxysmal atrial fibrillation (AF) refractory to antiarrhythmic drug therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis were performed. The primary outcome for the meta\u2010analysis was long\u2010term AF recurrence. Following the results of the meta\u2010analysis, the cost\u2010effectiveness of CBA versus RFA in Japan was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis included 12 randomized controlled trials and six propensity\u2010score matching cohort studies. AF recurrence was slightly lower in patients referred for CBA than for RFA, with an integrated risk ratio of 0.93 (95% confidence interval: 0.81\u20131.07) and an integrated hazard ratio of 0.96 (95% confidence interval: 0.77\u20131.19), but no significant difference was found. A cost\u2010minimization analysis was conducted to compare the medical costs of CBA versus RFA because there was no significant difference in the risk of AF recurrence between the procedures. The estimated costs for CBA and RFA were JPY 4\u2009858\u2009544 (USD 32\u2009390) and JPY 4\u2009505\u2009255 (USD 30\u2009035), respectively, with cost savings for RFA of JPY 353\u2009289 (USD 2355).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis suggests that CBA provides comparable benefits with regard to AF recurrence compared with RFA, as shown in previous studies. Although the choice of treatment should be based on patient and treatment characteristics, RFA was shown that it might be cost saving as compared to CBA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.13055","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T02:34:11Z","timestamp":1717986851000},"page":"802-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A meta\u2010analysis and cost\u2010minimization analysis of cryoballoon ablation versus radiofrequency ablation for paroxysmal atrial fibrillation"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1978-2097","authenticated-orcid":false,"given":"Yoshimi","family":"Nitta","sequence":"first","affiliation":[{"name":"Health Economics &amp; Reimbursement Japan Abbott Medical Japan LLC  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Reimbursement Japan Abbott Medical Japan LLC  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Shibahara","sequence":"additional","affiliation":[{"name":"CRECON Medical Assessment Inc  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7853-0202","authenticated-orcid":false,"given":"Teiichi","family":"Yamane","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430050045005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.15.194"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.076"},{"key":"e_1_2_9_7_1","unstructured":"NogamiA KuritaT AbeH AndoK IshikawaT ImaiK et\u00a0al.JCS\/JHRS 2018 guideline on non\u2010pharmacotherapy of cardiac arrhythmias [Internet]. 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