{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:06:34Z","timestamp":1771527994804,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The novel Confirm Rx\u2122 implantable cardiac monitor (ICM) with SharpSense\u2122 technology incorporates a new P\u2010wave discriminator designed to improve AF detection. This study aimed to evaluate the diagnostic performance of the Confirm Rx\u2122 ICM in detecting AF episodes of varying durations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter retrospective analysis of consecutive patients implanted with a Confirm Rx\u2122 ICM (v1.2) across nine UK hospitals, all with documented AF lasting at least 6\u2009min. Electrocardiograms (ECGs) were manually adjudicated by cardiologists. To account for intra\u2010 and inter\u2010reviewer variability, a random sample of 10% of ECGs underwent additional review. Disagreements were resolved by a third reviewer. Diagnostic performance was determined by calculating the gross and patient\u2010averaged positive predictive value (PPV) for AF episodes of different duration. The source of false positive (FP) detection was also categorized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 16,230 individual ECGs from 232 patients were included. The median AF episode duration was 14\u2009min. R\u2010wave amplitude remained stable during follow\u2010up (0.52\u2009\u00b1\u20090.27\u2009mV [initial] vs. 0.54\u2009\u00b1\u20090.29\u2009mV [end of follow\u2010up], <jats:italic>p<\/jats:italic>\u2009=\u2009.10). The gross and patient\u2010averaged PPV were 75.0% and 67.0%, respectively. Diagnostic performance (gross) increased with progressively longer AF episodes: 88.0% for \u22651\u2009h, 97.3% for 6\u2009h, and 100% for 24\u2009h. The main source of FP during tachycardia was T\u2010wave oversensing (54.2%), while in non\u2010tachycardic episodes it was predominantly ectopy (71.2%). The AF burden precision was excellent (93.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Confirm Rx\u2122 ICM diagnostic performance was modest for all AF episodes (75%), with accuracy increasing for longer AF episodes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.13124","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T01:54:35Z","timestamp":1725414875000},"page":"1093-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\u201cReal\u2010world\u201d performance of the Confirm Rx\u2122 <scp>SharpSense AF<\/scp> detection algorithm: <scp>UK<\/scp> Confirm Rx study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-6374","authenticated-orcid":false,"given":"Andre Briosa e","family":"Gala","sequence":"first","affiliation":[{"name":"Department of Cardiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T. B.","family":"Pope","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospitals Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Leo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhirup","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Engineering Science Institute of Biomedical Engineering University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Cardiology East Suffolk and North Essex NHS Foundation Trust  Colchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honey","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northumbria Healthcare NHS Foundation Trust  Wansbeck UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospitals Dorset NHS Foundation Trust  Bournemouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Cardiology Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy S.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Scottish National Advanced Heart Failure Service Golden Jubilee National Hospital  Glasgow 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University Hospitals Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton  Southampton UK"},{"name":"Department of Cardiology University Hospitals Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Betts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oxford University Hospitals NHS Foundation Trust  Oxford 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