{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:36:11Z","timestamp":1780508171511,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Micra\u2122 VR Transcatheter Pacing System (Micra VR) is a single\u2010chamber transcatheter leadless pacemaker. Absence of leads and subcutaneous pocket reduces or completely eliminates the risk of complications associated with the conventional transvenous pacemakers (TVPM). When compared with TVPM, the leadless technology provides a quicker postimplantation recovery and causes less cosmetic concerns\/discomfort providing better patient experiences in the long run. We performed a modeled cost\u2010utility analysis of Micra VR versus TVPM for the management of patients with bradycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a Markov model comparing Micra VR to TVPM over the device battery life of 17\u2009years. Key data inputs were drawn from the MICRA Coverage with Evidence Development (CED) study. Costs were obtained from Australian sources. The analysis is from the perspective of the Australian healthcare system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risks of complications, including device\u2010related events, in real\u2010world clinical practice were relatively low for TVPM. The magnitude of cost savings arising from risk reductions provided by Micra VR was however sizable, offsetting roughly a quarter of its additional device cost. Over the 17\u2010year model period, Micra VR was associated with an estimated incremental cost of A$4277 and an incremental quality\u2010adjusted life years (QALYs) of 0.09 when compared with TVPM, yielding an incremental cost\u2010effectiveness ratio of A$47\u2009379 per QALY gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Micra VR is likely to offer a cost\u2010effective alternative to the conventional TVPM technology for the management of patients with bradycardia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.13145","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T15:04:58Z","timestamp":1727449498000},"page":"1481-1489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cost\u2010effectiveness of Micra\u2122 <scp>VR<\/scp> leadless pacemaker in patients with bradycardia and atrial fibrillation in Australia"],"prefix":"10.1002","volume":"40","author":[{"given":"Koji","family":"Makino","sequence":"first","affiliation":[{"name":"THEMA Consulting Pty Ltd  Milsons Point New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Mudge","sequence":"additional","affiliation":[{"name":"THEMA Consulting Pty Ltd  Milsons Point New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4217-4836","authenticated-orcid":false,"given":"Michelle","family":"Hill","sequence":"additional","affiliation":[{"name":"Medtronic Australasia Pty Ltd  Macquarie Park New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Zaunmayr","sequence":"additional","affiliation":[{"name":"THEMA Consulting Pty Ltd  Milsons Point New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Tilden","sequence":"additional","affiliation":[{"name":"THEMA Consulting Pty Ltd  Milsons Point New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2022.09.016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz246"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.12.021"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.10.010"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1921573"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010018\u20100849\u20106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511643"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.01.035"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.08.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab767"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15863"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20102810"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12518"},{"key":"e_1_2_12_16_1","unstructured":"Australian Bureau of Statistics. Life Tables\u00a02019\u20132021 [cited 2023]. Available from:https:\/\/www.abs.gov.au\/statistics\/people\/population\/life\u2010tables."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008280"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X11401031"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104733.2008.00352.x"},{"issue":"11","key":"e_1_2_12_20_1","first-page":"810","article-title":"Pericarditis","volume":"46","author":"Rahman A","year":"2017","journal-title":"Aust Fam Physician"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab042"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.441"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13300"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.060"},{"key":"e_1_2_12_25_1","unstructured":"Micra Leadless Pacemakers Product Brochure.https:\/\/www.medtronic.com\/content\/dam\/medtronic\u2010wide\/public\/united\u2010states\/products\/cardiac\u2010vascular\/cardiac\u2010rhythm\/pacing\u2010systems\/micra\u2010vr2\u2010av2\u2010portfolio\u2010brochure.pdf. 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