{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:27Z","timestamp":1786978107762,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The guidelines recommend anticoagulation management with uninterrupted warfarin or direct thrombin inhibitors (DTIs) during the atrial fibrillation (AF) ablation periprocedural period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To clarify the Japanese real\u2010world latest periprocedural anticoagulation management during AF ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter observational study included 6232 consecutive AF patients (68.7\u2009\u00b1\u200910.9\u2009years, 4346 men) who underwent periprocedural anticoagulation therapy using direct oral anticoagulants (DOACs) between January 2022 and August 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean CHADS\n                      <jats:sub>2<\/jats:sub>\n                      and CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      VASc scores were 1.2\u2009\u00b1\u20091.1 and 2.3\u2009\u00b1\u20091.5. Bleeding and thromboembolic events occurred in 79 (1.3%) and eight (0.12%) patients. During the periprocedural period, factor Xa inhibitors (FXaIs) were used in 3063 patients (rivaroxaban in 624, apixaban in 1093, and edoxaban in 1345) and DTIs in 3170 including 2583 in whom DTIs were switched from FXaIs. Both the bleeding (0.85% vs. 1.69%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003) and thromboembolic event rates (0.03% vs. 0.23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.036) were significantly lower in the DTI\u2010 than FXaI\u2010group. A multivariate analysis showed periprocedural FXaI use was significantly associated with both bleeding events (odds ratio [OR]\u2009=\u20091.92, 95% confidence interval [CI]\u2009=\u20091.20\u20133.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006) and cardiac tamponade (OR\u2009=\u20092.74, 95% CI\u2009=\u20091.27\u20135.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01). The interval between the last DOAC administration and the procedure was significantly shorter in the DTI\u2010 than FXaI\u2010group (4.2\u2009\u00b1\u20094.9 vs. 19.3\u2009\u00b1\u200910.7\u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). In the FXaI\u2010group, the bleeding rate tended to be lower in the minimally interrupted (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092105) than uninterrupted group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009821) (1.47% vs. 2.56%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.06). Two patients in the uninterrupted FXaI\u2010group required surgical management for cardiac tamponade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our multicenter real\u2010world data demonstrated that anticoagulation with DTIs was a reasonable periprocedural anticoagulation regimen to reduce periprocedural complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.13182","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T03:43:34Z","timestamp":1736826214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010world clinical practice of current periprocedural anticoagulation management in catheter ablation of atrial fibrillation: Data from a large prospective ablation registry"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-3327","authenticated-orcid":false,"given":"Yuta","family":"Taomoto","sequence":"first","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Musashino Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-0934","authenticated-orcid":false,"given":"Shinsuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-5919","authenticated-orcid":false,"given":"Yasutoshi","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Musashino Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-3786","authenticated-orcid":false,"given":"Osamu","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Disaster Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yokosuka Kyosai Hospital  Kanagawa 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Soka Municipal Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Yamate Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yokohama Minami Kyosai Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Handa","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kashiwa City Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Hirao","sequence":"additional","affiliation":[{"name":"Arrhythmia Advanced Therapy Center AOI 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