{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:36:15Z","timestamp":1792640175134,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brugada syndrome (BrS) is an inherited cardiac channelopathy associated with a high risk of sudden cardiac death (SCD) due to ventricular fibrillation (VF). Although implantable cardioverter\u2010defibrillators (ICDs) are the primary therapy for SCD prevention, the risk stratification of elderly patients with BrS remains unclear. This study aimed to evaluate the incidence and risk factors of life\u2010threatening arrhythmias in elderly patients with BrS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 523 patients with BrS (mean age 51\u2009\u00b1\u200913\u2009years, 497 men) enrolled in the multicenter prospective Japan Idiopathic Ventricular Fibrillation Study. Patients were categorized into the elderly (&gt;60\u2009years,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009150) and nonelderly (\u226460\u2009years,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009373) groups. Clinical characteristics, programmed electrical stimulation (PES) results, and outcomes, including cardiac events (CEs: VF, fast ventricular tachycardia, or SCD), were compared. Statistical analyses were performed using Kaplan\u2013Meier curves and Cox proportional hazard models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a mean follow\u2010up of 106\u2009\u00b1\u200962\u2009months, 59 patients (11%) experienced CE. The annual CE incidence was lower in the elderly group than in the nonelderly group (0.7% vs. 1.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). History of VF independently predicted CE occurrence in elderly patients (hazard ratio: 23.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Asymptomatic elderly patients exhibited a negligible risk of CE. PES did not predict CE occurrence in the elderly group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elderly patients with BrS have a better prognosis than nonelderly patients, particularly if they are asymptomatic. A history of VF is a key risk factor for life\u2010threatening arrhythmias in elderly patients with BrS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70047","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T09:00:36Z","timestamp":1742893236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk stratification of elderly patients with Brugada syndrome: Results from a large Japanese cohort of idiopathic ventricular fibrillation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6106-6017","authenticated-orcid":false,"given":"Tetsuji","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University  Oita 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 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine Sakakibara Heart Institute  Fuchu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Daisan Kitashinagawa Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Senri Central Hospital  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-6153","authenticated-orcid":false,"given":"Masayasu","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Medical and Dental University  Tokyo 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