{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:39:01Z","timestamp":1768685941152,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011083","name":"Centre for Heart Rhythm Disorders, University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary vein isolation (PVI) remains the cornerstone of atrial fibrillation (AF) ablation. We previously demonstrated abnormal cardiac volume\u2010sensitive reflexes (whose receptors are co\u2010located in veno\u2010atrial tissue) in AF patients. Whether PVI disrupts afferent nerves is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate whether PVI disrupts afferent volume\u2010sensitive reflexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We consecutively studied autonomic reflexes in AF patients undergoing PVI, repeating the study post\u2010PVI, if AF\u2010free &gt;6\u2009months. We excluded patients with AF recurrence\/procedural complications, allowing repeat procedures. We measured beat\u2010to\u2010beat mean arterial pressure (MAP) and heart rate (HR) continuously during low\u2010level Lower Body Negative Pressure (LBNP), at 0, \u221220 and \u221240\u2009mmHg (predominantly testing volume baroreceptors); Valsalva reflex (predominantly arterial baroreceptors); and Isometric Handgrip reflex (IHR, both). LBNP produces reflex vasoconstriction, evaluated from forearm blood flow (FBF \u221d 1\/vascular resistance).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>18 patients were studied pre\u2010PVI; <jats:italic>n<\/jats:italic>\u2009=\u20099 completed both visits. Mean age was 64\u2009\u00b1\u20093\u2009years (78% male); BMI 28\u2009\u00b1\u20091\u2009kg\/m<jats:sup>2<\/jats:sup>; LA size 37\u2009\u00b1\u20092\u2009mL\/m<jats:sup>2<\/jats:sup>; and left ventricular function 65\u2009\u00b1\u20093%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre\u2010 versus post\u2010PVI. During LBNP, MAP decreased slightly both pre\u2010 (\u22121.6\u2009\u00b1\u20093%) and post\u2010PVI (\u22122.8\u2009\u00b1\u20091.8%); <jats:italic>p<\/jats:italic>\u2009=\u2009.7. HR increased similarly (<jats:italic>p<\/jats:italic>\u2009=\u2009.7) pre\u2010 (10.6\u2009\u00b1\u20096.4%) and post\u2010PVI (7.2\u2009\u00b1\u20091.5%). FBF response was unchanged (<jats:italic>p<\/jats:italic>\u2009=\u2009.8). Resting (arterial) baroreflex sensitivity was unaltered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PVI does not impair cardiovascular reflexes involving afferent baroreceptors, suggesting HRV changes reflect efferent modulation or ablation adequacy rather than afferent disruption. Whether disrupting sino\u2010atrial efferent nerves represents a marker of adequate ablation or influences PVI outcomes requires evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/joa3.70119","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T06:25:11Z","timestamp":1750746311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary vein isolation does not alter cardiovascular afferent autonomic reflexes in atrial fibrillation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-439X","authenticated-orcid":false,"given":"Varun","family":"Malik","sequence":"first","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian 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