{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:40:56Z","timestamp":1764312056863,"version":"3.46.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n The safety of including superior vena cava isolation (SVCI) along with pulmonary vein isolation (PVI) in atrial fibrillation (AF) patients with sick sinus syndrome (SSS) remains uncertain, as this decision is often left to the discretion of individual physicians.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In this retrospective study, 94\n AF<\/jats:styled-content>\n patients with\n SSS<\/jats:styled-content>\n , who underwent\n PVI<\/jats:styled-content>\n without prior pacemaker placement, were divided into two groups: those with (\n n<\/jats:italic>\n \u2009=\u200967, age 66.0\u2009\u00b1\u20099.3\u2009years, male 61%) and without (\n n<\/jats:italic>\n \u2009=\u200927, age 66.6\u2009\u00b1\u200910.0\u2009years, male 63%) additional empirical\n SVCI<\/jats:styled-content>\n .\n SVCI<\/jats:styled-content>\n was performed at 25\u201335\u2009\n W<\/jats:styled-content>\n , 10\u201320\u2009mm superior to the earliest sites of activation during sinus rhythm. The primary endpoint compared atrial tachyarrhythmia (\n ATA<\/jats:styled-content>\n ) recurrence, pacemaker avoidance, and 24\u2010hour ambulatory monitoring results between the SVCI and non\u2010SVCI groups. Preprocedure minimum heart rate (\n SVCI<\/jats:styled-content>\n 37.6\u2009\u00b1\u200911.6\u2009Bpm vs. non\u2010\n SVCI<\/jats:styled-content>\n 37.0\u2009\u00b1\u20099.9\u2009Bpm,\n p<\/jats:italic>\n \u2009=\u20090.74) and maximum pause (\n SVCI<\/jats:styled-content>\n 4.2\u2009\u00b1\u20092.7\u2009Sec vs. non\u2010\n SVCI<\/jats:styled-content>\n 3.6\u2009\u00b1\u20092.8\u2009Sec,\n p<\/jats:italic>\n \u2009=\u20090.15) were not different between the two groups. During 36\u2009months of follow\u2010up after the last procedure,\n ATA<\/jats:styled-content>\n recurrence rates (\n SVCI<\/jats:styled-content>\n 33% vs. non\u2010\n SVCI<\/jats:styled-content>\n 34%,\n p<\/jats:italic>\n \u2009=\u20090.82) and pacemaker avoidance rates (\n SVCI<\/jats:styled-content>\n 84% vs. non\u2010\n SVCI<\/jats:styled-content>\n 93%,\n p<\/jats:italic>\n \u2009=\u20090.32) Were Comparable between the two groups. At 36\u2009months after the last procedure, minimum heart rate (\n SVCI<\/jats:styled-content>\n 48.7\u2009\u00b1\u200910.2\u2009bpm vs. non\u2010\n SVCI<\/jats:styled-content>\n 47.4\u2009\u00b1\u20098.3\u2009bpm,\n p<\/jats:italic>\n \u2009=\u20090.52) and maximum pause (\n SVCI<\/jats:styled-content>\n 1.6\u2009\u00b1\u20091.0\u2009sec vs. non\u2010\n SVCI<\/jats:styled-content>\n 1.6\u2009\u00b1\u20090.6\u2009sec,\n p<\/jats:italic>\n \u2009=\u20090.33) remained similar between the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this study, the addition of\n SVCI<\/jats:styled-content>\n did not significantly increase the need for pacemaker implantation or lead to sinus node dysfunction in\n AF<\/jats:styled-content>\n patients with\n SSS<\/jats:styled-content>\n compared to\n PVI<\/jats:styled-content>\n alone.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/joa3.70126","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T04:25:15Z","timestamp":1751257515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mid\u2010term effects on sinus node function following additional empirical superior vena cava isolation in atrial fibrillation patients with sick sinus syndrome"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-691X","authenticated-orcid":false,"given":"Miwa","family":"Kanai","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Medical Center Yachiyo Japan"},{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-3140","authenticated-orcid":false,"given":"Satoshi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"},{"name":"Clinical Research Division for Heart Rhythm Management Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-434X","authenticated-orcid":false,"given":"Yuko","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigo","family":"Yagishita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"},{"name":"Clinical Research Division for Heart Rhythm Management Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1772-6823","authenticated-orcid":false,"given":"Morio","family":"Shoda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"},{"name":"Clinical Research Division for Heart Rhythm Management Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University Yachiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.02.030"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12342"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.005"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2015.4.1.28"},{"issue":"1","key":"e_1_2_13_6_1","first-page":"4","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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